Control of Schistosomiasis in the Lakes Region of China by Eliminating Parasites in Livestock: Combined Treatment Strategy Employing Praziquantel + Administration of an Anti-Schistosoma Japonica ?


Principal Investigator:
Donald Harn, Professor of Tropical Public Health

Department of Immunology and Infectious Diseases

Dates of Research:
March 1, 2005 — February 28, 2010


Schistosomiasis japonicum is a zoonotic disease of man and many mammals. In China, this disease remains a major public health problem in the lakes and marsh regions. A mathematical model suggests that water buffalo account for 80% of transmission of this disease in these regions of China, and that use of a vaccine which reduces parasite egg output in buffalo feces by 40-50%, will, in combination with drug treatment, reduce transmission to near eradication levels. The first phase of this study is an evaluation of vaccine efficacy in water buffalo testing SjC23 and SjCTPI plasmid DNA vaccines singly and in combination. The second phase is a large field trial using vaccines alone, praziquantel alone, vaccines and praziquantel, vs sham treated buffalo and determining impact of these treatments on reducing transmission.