Development and Evaluation of HPV Vaccines and Related Diagnostics


Principal Investigator:
Susanne Goldie, Roger Irving Lee Professor of Public Health

Center for Health Decision Science

Bill and Melinda Gates Foundation

Dates of Research:
December 1, 2004 — December 1, 2011


In response to new etiologic evidence, improved technology, and promising HPV vaccine efforts, cervical cancer epidemiologic and preventative efforts are being reshaped throughout the world. The objective of this project is to develop a computer-based model to guide the development of HPV vaccines and related diagnostics, and evaluate the feasibility, effectiveness, and cost-effectiveness of global cervical cancer prevention strategies to reduce morbidity and mortality from the leading cause of cancer death among women in developing countries. This model will provide a durable tool that will be used iteratively in all phases of a well-coordinated major global initiative to reduce HPV-related cervical cancer. Using an iterative approach to combine empiric data collection with decision analytic modeling this project will intersect with all three strategic approaches of the foundation (build, prove, and sustain) and will contribute to the development, application and sustainability of global HPV vaccine efforts.