Early and Acute HIV-1 Subtype C Infection in Botswana


Principal Investigator:
Vladimir Novitsky

Department of Immunology and Infectious Diseases

Dates of Research:
July 1, 2003 — June 30, 2005


HIV-1 subtype C is the dominant HIV-1 subtype C in the AIDS epidemic. Botswana, a country in southern Africa with an estimated HIV prevalence of about 35-40%, provides the epidemiologic and laboratory infrastructure for this study. The purpose of this study is to identify individuals as early as possible in HIV-1C infection and characterize viral and immune parameters in acute HIV-1C infection. The study is an extension of the HIV Vaccine Preparedness Study and will examine that prospective cohort of 500 uninfected individuals at high risk for HIV infection in Botswana.