Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort


Principal Investigator:
Joel Schwartz, Professor

EH-Exposure, Epidemiology and Risk Program

Dates of Research:
September 25, 2006 — August 31, 2011


Cardiovascular disease (CVD) is the leading cause of death among the elderly in the United States. As the percentage of the population living over the age of 75 increases, there will also be a dramatic increase in the number of persons dying from CVD. The goal of this study is to determine whether exposure to air particles and toxic metals (arsenic, cadmium, and lead) increases CVD risk by altering global and/or gene specific methylation in elderly subjects over time.