Folate, One-Carbon Nutrients, Gene Variants and Colon Cancer


Principal Investigator:
David Hunter, Vincent L. Gregory Professor in Cancer Prevention

Department of Epidemiology

Dates of Research:
September 18, 2003 — August 31, 2009


The overall long-term objective of this project is to establish the role of folate and other nutritional contributors to one-carbon metabolism in colorectal cancer by combining animal, mechanistic, human observational studies and clinical trials. These studies will help integrate epidemiologic and mechanistic observations and help provide a basis for public health recommendations on optimal levels of folate a B vitamin intake.