Gene-environment EBV Interactions in the Etiology of Nasopharyngeal Carcinoma (NPC)

, ,

Principal Investigator:
Hans-Olov Adami, Professor of Epidemiology



Dates of Research:
September 22, 2008 — July 31, 2012


Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Southeast Asia, yet little is known about causes. This study will examine genetic, viral, and environmental risk factors for NPC in southern China, where NPC rates are among the highest in the world. Our goal is to identify new ways to prevent NPC, as well as to improve the identification of high-risk individuals for early detection and successful treatment of NPC. Building on the collective experience of the Harvard School of Public Health in Boston, as well as many other cancer centers around the world, this project consists of a population-based case-control study in two provinces in southern China with a total of 2,000 incident cases and an equal number of population controls. The project will include face-to-face interviews, collection of tumor tissue and blood, and genotyping and other laboratory analyses. The large size of the study provides sufficient statistical power to detect main effects of genetic and environmental exposures. The study also develops a biological bank of tissue, serum, and DNA which will be made available for other investigators and future genetic studies.