Genetic Epidemiology of COPD in Costa Rica


Principal Investigator:
Christoph Lange

Department of Biostatistics

Brigham & Women's Hospital

Dates of Research:
February 1, 2008 — January 31, 2010


This application will examine the genetic factors that influence the development of chronic-obstructive pulmonary disease (COPD) in Hispanics, a minority group at high risk for the disease. To this end, we will concentrate on a genetically isolated Hispanic population with a high prevalence of COPD living in the Central Valley of Costa Rica. To identify regions of the genome likely to contain genetic determinants of COPD-related phenotypes in this population, we will utilize a study design that entails collection of phenotypic and genotypic data on 30 large families of probands with moderate to severe COPD that have multiple individuals affected with smoking-related airflow obstruction, comprising 900 individuals from descendants of the Costa Rican Central Valley founder population. By utilizing a family-based study design with a large sample size in a genetically isolated population, the study will address the important yet unstudied problem of the genetic influences on the expression of the COPD phenotype in Hispanics. The study will not only contribute to our understanding of the pathogenesis of COPD in Hispanics, but also of COPD in general.