Genomewide Search for Loci Underlying Metabolic Syndrome


Principal Investigator:
Xin Xu, Mark and Catherine Winkler Assistant Professor of Genetic Epidemiology

Department of Environmental Health and Department of Epidemiology


Dates of Research:
September 29, 2003 — August 31, 2009


Metabolic syndrome, characterized by clustering of multiple metabolic abnormalities including abdominal obesity, dyslipidemia, hyperinsulinemia, hyperglycemia, and hypertension, is an important risk factor of cardiovascular disease. Genetics plays a significant role in determining the individual susceptibility to metabolic syndrome and the inter-individual variation in its associated phenotypes, though these genetic factors remain largely unknown. The major goals of this project are to study the underlying phenotypic structure of metabolic syndrome in a Chinese cohort and to systematically search for genetic loci predisposing metabolic syndrome using the genome scan approach.