Health of HIV-Infected Mothers after pMTCT, Botswana


Principal Investigator:
Shahin Lockman, Assistant Professor in the Department of Immunology and Infectious Diseases

Department of Immunology and Infectious Diseases

Dates of Research:
September 5, 2003 — February 28, 2009


Maternal health concerns are an important but understudied aspect of programs designed to prevent mother-to-child HIV-1 transmission in the developing world. Two of the most important and urgent questions regarding maternal health in this context are whether breastfeeding by HIV-infected women is associated with excess maternal morbidity and mortality and the response to nevirapine-containing combination antiretroviral therapy among women who have previously taken the drug to prevent transmission to the child. HIV-infected mothers enrolled in this clinical trial in Botswana will be either administered treatment while breastfeeding their infant or the infant will be formula fed. Women in the study will also be offered the Government HIV treatment program. The study provides the opportunity to answer questions that have significant public health implications regarding the health of HIV-infected mothers and their infants.