Helminth infection and the risk of tuberculosis in children

Country/Countries:

Principal Investigator:
Molly Franke

Department:
Department of Epidemiology

Dates of Research:
September 30, 2007 — September 29, 2008

Description:

In 2000, an estimated 884,019 children under the age of 15 became ill with tuberculosis (TB). Despite the existence of treatments, the World Health Organization has estimated that approximately one third of TB cases among children in that age group result in death. By identifying modifiable risk factors, new interventions could be developed that could substantially decrease TB-related death. One such risk factor could be helminth infection, including round worm and hookworm infection. The objective of this study is to examine whether helminth infection increases susceptibility to TB infection and TB disease in children. The project, conducted in Lima, Peru, compares the prevalence of helminth infection among children with and without TB disease to identify whether helminth is a risk factor for active TB disease or TB infection.