HIV-1 Vaccine Based on Chimp Serotypes and Adenovirus

Country/Countries:

Principal Investigator:
Myron Essex

Department:
Department of Immunology and Infectious Diseases

Dates of Research:
September 1, 2007 — August 31, 2009

Description:

This program focuses on vaccine candidates for HIV-1 based on chimpanzees. Definitions of the characteristics of effective immune response in animals with comparison studies in human vaccine recipients will advance our understanding of the correlates of the immune protecting to be pursued in future efforts of AIDS vaccine development. The program will address multiple goals including define the quality of T cell responses, testing the safety in dose-escalation phase trials, and further optimizing the study areas for later stage clinical trials.