HIV Positive and Pregnant: Contributing Factors and Outcomes


Principal Investigator:
Richard Marlink, Bruce A. Beal, Robert L. Beal, and Alexander S. Beal Professor of the Practice of Public Health

HSPH AIDS Initiatives

African Comprehensive HIV/AIDS Partnership

Dates of Research:
February 1, 2009 — December 31, 2010


In order to uncover and explore the intersection of the structural, personal, and biological factors which affect the sexual and reproductive health of HIV-positive women, this research will be use a mixed-method approach by combining quantitative data collected through surveys with date from enriching qualitative in-depth interviews and focus group discussions. The study will examine sexual and reproductive health issues, particularly childbearing, among various group of HIV-positive women, including pregnant women who knew their HIV status before becoming pregnant(both those on HAART and those who are not), as well as women on HARRT who are not pregnant. The study will be conducted in both urban and rural settings, namely Gaborone and Mochudi. Gaborone, the capital city of Botswana, will include a total of five MASA ARV Therapy Clinics known as IDCC’s (infectious Disease Care Clinics), in addition to 15 ante-natal clinics offering PMTCT. Mochudi, which is a village 30 kilometers from Gaborone, will include the IDCC located at the Deborah Retief Memorial Hospital, as well as ANC clinics in the hospital catchment area. A population-based cohort of pregnant women with known HIV status will be sampled from overall population of women seeking ante-natal care in these two settings. Within this cohort will be a nested case-control study of HIV-positive pregnant women on HAART(cases) and HIV- positive non-pregnant women on HAART(controls). We anticipate enrolling a totally of 125 pregnant and 250 non-pregnant HIV-positive women on HAART for the nested case-control study.