Host Genetics of HIV-1 Subtype C Infection, Progression, and Treatment in Africa

Country/Countries:
,

Principal Investigator:
Myron Essex, Mary Woodard Lasker Professor of Health Sciences

Department:
Immunology+Infectious Diseases Prime

Dates of Research:
May 17, 2007 — April 30, 2012

Description:

Previous studies on host susceptibility genes for HIV/AIDS have focused on Caucasian men infected with HIV-1B. This represents a major disconnect with the population at greatest risk, women infected with HIV-1C in southern Africa. Little is known about the role of host genetic factors on non-B HIV-1 infection and progression or on highly active antiretroviral therapy (HAART) response in African populations. Botswana has led the region in the use of HAART. This study seeks to investigate whether the genetic factors affecting risk of HIV-1 disease may be different in southern African heterosexuals infected with HIV-1 C which would explain in part the higher prevalence, differences in disease patters, and the spectrum of adverse events related to HAART.