Identifying Phenotypic and Genotypic Diversity in M. Tuberculosis Strains Using Functional Genomics

Country/Countries:

Principal Investigator:
Sarah Fortune, Assistant Professor

Department:
Immunology+Infectious Diseases 050

Dates of Research:
August 15, 2008 — August 31, 2010

Description:

The Howard Hughes Medical Institute (HHMI) supports scientific research at the University of KwaZulu-Natal in Durban, South Africa to study the biological bases, prevention, and treatment of the AIDS and TB epidemics, and to help educate a new generation of scientist in South Africa and elsewhere. HHMI is supporting research work directed by Sarah Fortune in order to enable research and training activities that further the mission of this research and effort in South Africa. This project investigates whether strains of M. tuberculosis circulating in South Africa vary in biologically significant ways. The project seeks to prove that those function differences contribute to differences in the course of primary disease and in response to treatment.