Vladimir Novitsky, Principal Research Scientist
Immunology+Infectious Diseases Prime
Dates of Research:
May 1, 2005 — April 30, 2011
Most HIV vaccine designs are currently based on studies of chronic HIV-1 subtype infection. However, the prevailing dominance of HIV-1 subtype C in the worldwide AIDS epidemic necessitates a comprehensive analysis of primary HIV-1 C infection with regard to vaccine design. This study will focus on acute and early HIV-1 infection in Botswana. The study will characterize the magnitude, breadth and kinetics of virological and immunological determinants during primary HIV-1 C infection as well as the association between virological and immunological markers in primary HIV-1 C infection with viral set point.