Markers of Viral Set Point in Primary HIV-1C Infection

Country/Countries:
,

Principal Investigator:
Vladimir Novitsky, Principal Research Scientist

Department:
Immunology+Infectious Diseases Prime

Dates of Research:
May 1, 2005 — April 30, 2011

Description:

Most HIV vaccine designs are currently based on studies of chronic HIV-1 subtype infection. However, the prevailing dominance of HIV-1 subtype C in the worldwide AIDS epidemic necessitates a comprehensive analysis of primary HIV-1 C infection with regard to vaccine design. This study will focus on acute and early HIV-1 infection in Botswana. The study will characterize the magnitude, breadth and kinetics of virological and immunological determinants during primary HIV-1 C infection as well as the association between virological and immunological markers in primary HIV-1 C infection with viral set point.