Mechanics of Monolayer Migration

Country/Countries:
,

Principal Investigator:
Jeffrey Fredberg, Professor of Bioengineering and Physiology

Coinvestigators:
Butler, Trepat, Zaman

Department:
EH-Molecular+IntegrativePhysiologicalSciences

Dates of Research:
April 6, 2011 — March 31, 2012

Description:

Cells in the lung often migrate not as individual entities but as collective sheets, ducts, strands, or clusters. But how each cell can coordinate its migration with that of immediate neighbors has defied full comprehension. This study proposes the hypothesis that a much overlooked but nonetheless central feature of coordinated cellular migration is that each constituent cell can become physically constrained (jammed) by nearest neighbors.