Modeling Human Exposure-Dose Relationships: 1,3-Butadiene

Country/Countries:

Principal Investigator:
Thomas Smith, Professor of Industrial Hygiene

Department:
Exposure, Epidemiology and Risk Program

Dates of Research:
September 16, 2002 — December 31, 2007

Description:

This study will develop and conduct the GC- or HPLC-AMS analyses of breath, blood, and urine samples by exposing subjects to carbon-14 labeled butadiene. This will include developing methods to prepare the biological samples for mass balance analysis and determination of specific butadiene metabolites.