Wafaie Fawzi, Richard Saltonstall Professor of Population Sciences, and Professor of Nutrition,
Dates of Research:
September 30, 2008 — July 31, 2012
The objective of this study is to determine the efficacy of high-dose multivitamins for improving immunologic control as well as clinical outcomes related to disease, among HIV-positive Ugandans receiving HAART therapy. Highly active anti-retroviral therapy (HAART) has dramatically reduced disease progression for HIV-infected adults in developing countries. However, gains in virologic and immuniologic control are often incomplete and unsustainable, and treatment can be associated with adverse toxic effects that necessitate multiple changes in drug regimens. Notably, high-dose multivitamin supplements have improved immune status and clinical outcomes among HIV-infected adults in Tanzania who were in pre-HAART stages of disease.