Petros Koutrakis, Professor of Environmental Sciences
EH-Exposure, Epidemiology and Risk Program
Environmental Protection Agency
Dates of Research:
October 1, 2005 — September 30, 2011
This study will undertake a double-blind, randomized block study with controlled human exposures to fine, ultrafine and coarse CAPs, using a particle-free air exposure as a control. Each of the 50 healthy adults will receive 4 exposures in random order and separated by at least two weeks. Cardiovascular outcomes will be measured with both pre- and post-exposure (immediately and 24 hours after) and will include measures of: brachial artery diameter, flow-mediated dilatation and nitroglycerin-mediated dilation, stroke volume and cardiac output, blood pressure, and venous blood CBCs, IL6, CRP, and endothelins.