Novel Regulators of the Osteoclast Differentiation Program


Principal Investigator:
Antonios Aliprantis

Department of Immunology and Infectious Diseases

Burroughs Welcome Fund

Dates of Research:
September 1, 2008 — August 31, 2009


Bone is a dynamic tissue that continuously remodels to preserve the structural integrity of the skeleton. Adult bone mass is determined by the rates of bone formation by osteoblasts and bone resorption by osteoclasts. Functional dysregulation of these cells contributes to the pathogenesis of skeletal disorders, including osteoporosis, which afflicts 10 million Americans over the age of 50. This grant aims to expand our understanding of the transcriptional and signaling networks that govern the behavior of the osteoclast, the only cell capable of bone resorption.