Optimal Combination Therapy After Nevirapine Exposure (OCTANE): Adult AIDS Clinical Trials Group A5208

Country/Countries:

Principal Investigator:
Shahin Lockman, Assistant Professor in the Department of Immunology and Infectious Diseases

Department:
Department of Immunology and Infectious Diseases

Dates of Research:
April 1, 2005 — December 31, 2007

Description:

A5208/OCTANE is a phase III study comprising two randomized clinical trails to be conducted concurrently. Both trials will compare the virologic response to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based versus protease inhibitor (PI)-based antiretroviral treatment (ART) in HIV-infected treatment-naïve women. Trial1 will evaluate the superiority of PI-based ART over NNRTI-based ART in women with prior single dose (SD) nevirapine (NVP) prophylaxis for mother-to-child-transmission (MCTC) of HIV. Trial 2 will evaluate the equivalence of PI and NNRTI-based ART in women with no prior NVP exposure.