Projects

Genomewide Search for Loci Underlying Metabolic Syndrome

Metabolic syndrome, characterized by clustering of multiple metabolic abnormalities including abdominal obesity, dyslipidemia, hyperinsulinemia, hyperglycemia, and hypertension, is an important risk factor of cardiovascular disease. Genetics plays a significant role in determining the individual susceptibility to metabolic syndrome and the…

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International Training in AIDS-Related Epidemiology

Faculty associated with the university-wide Harvard AIDS Institute (HAI) and especially the Harvard School of Public Health (HSPH) have developed strong programs for AIDS research training in collaboration with 6 developing countries: Senegal, Tanzania, Botswana, Thailand, Nigeria, and China. The…

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Alcohol Use and the Risk of HIV-1 Infection in Botswana

The World Health Organization has estimated that more than 36 million adults and children have been infected with HIV-1 worldwide. In sub-Saharan Africa, the AIDS pandemic has been most severe, with more that 25 million individuals living with HIV-1. In…

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Dietary Fatty Acids, PPAR Activated Genes and CHD

Coronary heart disease (CHD) is the major cause of death in most industrialized and developing countries. Links between genetic and dietary factors that modify the risk of CHD should give fundamental insight into its causes and improve population-based CHP prevention…

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Monitoring HAART in HIV-Infected Parents in Thailand

Implementation of highly active antiretroviral therapy (HAART) has led to a substantial decrease in HIV-related mortality and morbidity. With this important advance, however, has come a monitoring and decision-making process whose complexity challenges the medical care system, particularly in regions…

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Health of HIV-Infected Mothers after pMTCT, Botswana

Maternal health concerns are an important but understudied aspect of programs designed to prevent mother-to-child HIV-1 transmission in the developing world. Two of the most important and urgent questions regarding maternal health in this context are whether breastfeeding by HIV-infected…

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Bioengineering Analysis of Muscle Mechanics and Metabolism

Using the methods of engineering analysis, this study will develop a computational platform that incorporates current knowledge of molecular structure, biochemical energetics, and contraction kinetics to describe muscle contraction. The goal of this research project is to develop a comprehensive…

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Early and Acute HIV-1 Subtype C Infection in Botswana

HIV-1 subtype C is the dominant HIV-1 subtype C in the AIDS epidemic. Botswana, a country in southern Africa with an estimated HIV prevalence of about 35-40%, provides the epidemiologic and laboratory infrastructure for this study. The purpose of this…

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The Cardiopulmonary Effects of Particulate Exposure

Although studies (some from Beijing, China) suggest a relationship between particulate air pollution and increased COPD mortality and morbidity, the underlying mechanisms remain unknown. Why an increased cardiovascular mortality is associated with PM is unclear. In Beijing PM air pollution,…

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AIDS: International Training and Research Program

The AIDS International Research and Training Program (AITRP) goals are to: (1) develop a “”critical mass”” of invesitgators capable of conducting state-of the-art clinical, epidemiological, operational, biomedical, and behavioral HIV prevention and treatment research and (2) to build research infrastructure…

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Botswana HIV Vaccine Trials Unit-Core Funds

An HIV Vaccine Trials Unit (HVTU) has been established at the Botswana-Harvard AIDS Institute Partnership site in Gaborone, Botswana. Its ongoing operation will allow HIV Vaccine Trials Network (HVTN) protocols and related research to be conducted in Botswana.

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