PHACS – Data and Operations Center

Country/Countries:

Principal Investigator:
George Seage, Associate Professor

Department:
Epidemiology

Sponsors:
NIH/NICHD

Dates of Research:
September 30, 2005 — July 31, 2010

Description:

The goal of the PHACS Data and Operations Center is to understand the clinical course of perinatally acquired HIV infection among adolescents and pre-adolescents, and the consequences of fetal and neonatel exposure to HIV and antiretroviral chemotherapy among a representative cohort of children in the United States. The National Institutes of Child Health and Human Development (NICHD) intends to establish the Pediatric HIV/AIDS Cohort Study (PHACS) to conduct research among two cohorts: A cohort of perinatally infected adolescents and preadolescents (age 7-18) will be established to evaluate the impact of HIV and ART on sexual maturation, pubertal development, and socialization, and a drug toxicity surveillance system among perinatally HIV exposed uninfected children will evaluate long-term effects of in-utero ART exposure. In addition to collaborating to define the PHACS research agenda, during year 1 we will provide methodological support for the development of all PHACS analytic projects, develop the (base and uninfected) core protocols, develop and support an active CAB, write and manage a site solicitation, establish site sub-contracts, obtain and merge all preexisting data bases from previous cohorts (PACTG 219/219C, WITS, PSD), plan and conduct all LG and full PHACS Network Meetings. In years 2-5, we will continue to provide design, methodological, and analytic expertise and support to the development of PHACS research protocols; train and monitor sites in proper procedures for PHACS research.

Website: https://phacs.nichdclinicalstudies.org/default.asp