The Cardiopulmonary Effects of Particulate Exposure


Principal Investigator:
David Christiani, Professor of Occupational Medicine and Epidemiology

Department of Environmental Health and Department of Epidemiology


Dates of Research:
July 1, 2003 — March 31, 2009


Although studies (some from Beijing, China) suggest a relationship between particulate air pollution and increased COPD mortality and morbidity, the underlying mechanisms remain unknown. Why an increased cardiovascular mortality is associated with PM is unclear. In Beijing PM air pollution, cardiovascular disease and COPD are rising. The primary objective of this study is to assess the role of particulate air pollution and changes in cardiovascular parameters in a selected group of adults in a populous district in central Beijing. We will assess the role of PM and the contribution of underlying chronic lung disease, and physiologic changes in heart function that may be important markers of cardiovascular dysfunction. The study will also assess the role of candidate genes in pulmonary parameters and the role of smoking, candidate genes, and physiologic changes in pulmonary function that may be important markers of COPD.