Training in Malaria Pathogenesis and Diversity in Africa


Principal Investigator:
Dyann Wirth, Richard Pearson Strong Professor of Infectious Disease

Immunology+Infectious Diseases 050

Dates of Research:
August 4, 2005 — April 30, 2012


Malaria remains a major cause of morbidity and mortality throughout Africa and attempts to control the disease through drug treatment, vaccine development and insect vector control have met with limited success. Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts efforts to control disease. Drug resistance to chloroquine has spread from Asia throughout Africa and resistance to second and third line drugs is now commonplace. This project will develop a training program to expand the capabilities of scientists and health professionals in Senegal with the goal of strengthening the scientific foundations for malaria research in the country. This research training program emphasizes two major areas of malaria research: pathogenesis, immunology, invasion, and parasite diversity and epidemiology and clinical disease characteristics. The long-term objective of this program is to train scientists and health professionals from Senegal who will become experts in malaria and contribute significantly to the advancement of malaria research in their own country and other African nations.