Trial of Vitamins Among Children of HIV-Infected Mothers


Principal Investigator:
Wafaie Fawzi, Professor of Nutrition and Epidemiology

Department of Nutrition

Dates of Research:
June 9, 2003 — May 31, 2009


An increasing body of evidence supports the efficacy of single, and more recently, multiple micronutrient supplementation in reducing morbidity and mortality in susceptible populations. This project will evaluate the efficacy of multiple micronutrient supplementations in susceptible children. Children born to HIV-infected women are at risk of multiple micronutrient deficiencies due to poor dietary intake, malabsorption, and increased metabolic needs. In addition, these children, if infected with HIV themselves, are at significantly higher risk of death due to infectious illness than their non-infected peers. This study will study the efficacy of micronutrient supplementation in reducing the risk of death and other adverse health outcomes among infants and young children born to HIV-positive Tanzanian women. Researchers will monitor mortality as well as occurrence of diarrhea, respiratory tract infection, weight and length gain, and HIV transmission. The study is part of a collaborative effort between the Harvard School of Public Health and Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania.