Professor of Radiobiology
Director of the John B. Little Center
Yuan Laboratory Research Focus
The cellular responses to stress in general, and to radiation in particular, are highly coordinated processes, which, when deregulated, may contribute to the development of stress-associated pathologies and diseases including aging, diabetes and cancer. Our research focuses on elucidation of signaling mechanisms that regulate cellular stress responses and on examining how stress signals affect cell behaviors in the context of cancer. Our long term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer.