Research People Publications Software Links	Department of Biostatistics, Harvard School of Public Health Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute Address: Room 11036, Center for Life Sciences, 3 Blackfan Circle, Boston, MA 02115 Contact: cli@hsph.harvard.edu, 617-632-3498 We are a computational biology lab with application interests in cancer and neuroscience. The current emphasis is to develop analysis methods and software for high-throughput gene expression and SNP microarray data. Genomic alteration analysis using SNP arrays. · Develop methods to identify LOH and copy number changes in tumor samples with or without paired normals (ref, 2, 3). · Integrate with other genomics data such as gene expression arrays, using myeloma samples (ref). dChip software. We are dedicated to developing and maintaining the user-friendly and free microarray analysis software dChip (manual). · dChip provides many analysis and visualization methods for gene expression and SNP microarray data and has been used in many research applications. · It is the first software to perform model-based analysis of oligonucleotide expression array data and one of the first to perform copy number and LOH analysis of SNP arrays. · New analysis methods are constantly developed and tested in dChip through collaborative projects and then provided for broader use. Current research support: National Institutes of Health.