Agenda

THURSDAY, NOVEMBER 5, 2015

8:30-9:00am  Registration & Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda

9:00  Opening Remarks


SESSION I : Emerging Technologies for Genome-scale Single-cell Analysis

9:00-9:45
George Church | KEYNOTE SPEAKER
Harvard Medical School and MIT
In situ Omics & the BRAIN initiative

9:45-9:50  Questions and Discussion

9:50-10:15
James Eberwine
University of Pennsylvania Perelman School of Medicine
Single Cell/Subcellular Variability and Theories of Cellular Phenotype

10:15-10:20  Questions and Discussion

10:20-10:30
Stephanie Hicks – Abstract Winner
Dana-Farber Cancer Institute / Harvard Chan School
On the widespread and critical impact of systematic bias and batch effects in single-cell RNA-Seq data

10:30-10:35  Questions and Discussion

10:35-11:00  BREAK

11:00-11:25
William Greenleaf
Stanford School of Medicine
Single-cell chromatin accessibility reveals principles of regulatory variation

11:25-11:30  Questions and Discussion

11:30-11:55
Kun Zhang
University of California, San Diego
Sequencing and Mapping of RNA Molecules in Human Adult Brain

11:55-12:00  Questions and Discussion

12:00-1:00  LUNCH

1:00 – 1:15   
Special Talk Bob Jones, Fluidigm
New Tools for Single-Cell Biology


SESSION II : Computational Methods for Analyzing Single-cell Genomic Data

1:15-2:00
Michael Elowitz | KEYNOTE SPEAKER
California Institute of Technology
An operational perspective on mammalian signaling and epigenetic memory circuits using synthetic biology and single-cell dynamics

2:00-2:05  Questions and Discussion

2:05-2:30
Sylvia Plevritis
Stanford School of Medicine
Optimizing Combination Cancer Therapy Based on Single Cell Analysis

2:30-2:35  Questions and Discussion

2:35-3:00
Raphael Gottardo
Fred Hutchinson Cancer Research Center
MAST: A novel statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data

3:00-3:05  Questions and Discussion

3:05-3:30  BREAK

3:30-3:40
Martin Hemberg – Abstract Winner
Wellcome Trust Sanger Institute
SC3 – Consensus clustering of single-cell RNA-seq data

3:40-3:45  Questions and Discussion

3:45-4:10
John Marioni
European Bioinformatics Institute
Using Single-cell Genomics to Study Early Development

4:10-4:15  Questions and Discussion

4:15-6:15  Poster Session and Reception | 2nd floor lounge

FRIDAY, NOVEMBER 6, 2015

8:30-9:00am  Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda


SESSION III : Applications of Single-cell Technologies in Human Health and Diseases

9:00-9:45
Sten Linnarsson | KEYNOTE SPEAKER
Karolinska Institutet
Molecular Anatomy of the Mouse Brain by Single-cell RNA-seq

9:45-9:50  Questions and Discussion

9:50-10:15
Galit Lahav
Harvard Medical School
Connecting protein dynamics with drug resistance in individual cells

10:15-10:20  Questions and Discussion

10:20-10:45
Nicholas Navin
MD Anderson Cancer Center
Investigating Clonal Evolution with Single Cell Genomics

10:45-10:50  Questions and Discussion

10:50-11:00
Michalina Janiszewska – Abstract Winner
Dana-Farber Cancer Institute / Harvard Chan School
The effect of chemotherapy on HER2+ breast cancer heterogeneity measured by STAR-FISH: Detection of PIK3CA mutation and HER2 amplification at single-cell level in situ

11:00-11:05  Questions and Discussion

11:05-11:30
Catherine Wu
Dana-Farber Cancer Institute & Harvard Medical School
Precise dissection of genetic and transcriptional heterogeneity in chronic lymphocytic leukemia by single cell analysis

11:30-11:35  Questions and Discussion

11:35  Closing Remarks