Poster Session

Session I: Identifying causal genes and pathways

Presenter & Slack Link Poster Number, Title, & Authors
Lilit Antonyan

https://pqg2020.slack.com/archives/C01D8LM1WUE

1. Genome-Wide Association Study on Obsessive Compulsive Traits Using a Quantitative Symptom Measure

Lilit Antonyan, S-M Shaheen, Gregory Hanna, David Rosenberg, Paul Arnold

Diana Avalos

https://pqg2020.slack.com/archives/C01DMSHRF6Y

2. Genetic variation in cis regulatory domains and trans regulatory hubs of immunity

Diana Avalos*, Guillaume Rey*, Anna Ramisch, Olivier Delaneau, Emmanouil T Dermitzakis

Jenna Ballard

https://pqg2020.slack.com/archives/C01D90F966A

3. Characteristics beyond correlation in multi-trait effect-size distributions

Jenna L Ballard and Luke J O’Connor

Arjun Battacharya

https://pqg2020.slack.com/archives/C01DCKE55HB

4. MOSTWAS: Multi-omic strategies for transcriptome-wide prediction and association studies

Arjun Bhattacharya, Yun Li, Rebecca C. Fry, Hudson P. Santos Jr, Michael I. Love

Carles Boix

https://pqg2020.slack.com/archives/C01D108PVNKkn

5. Integrative analysis of 10,000 epigenomic maps across 800 samples for regulatory genomics and disease dissection

Carles Boix, Ben James, Yongjin Park, Wouter Meuleman, Manolis Kellis

Brielin Brown

https://pqg2020.slack.com/archives/C01D1096W2K

6. Phenome-scale directed network discovery with bi-directional mediated Mendelian randomization

Brielin C Brown, David A Knowles

Terence Capellini
https://pqg2020.slack.com/archives/C01DMSTSSAY
honorable mention7. Separate regulatory variants on a common risk haplotype at GDF5-UQCC1 underlie knee osteoarthristis risk and developmental dysplasia of the hip in vivo

Terence D. Capellini, Pushpanathan Muthuirulan, Zun Liu, Ata M. Kiapour, Jiaxue Cao, Jakob Sieker, Siddharth Yarlagadda, David E. Maridas, Vicki Rosen, Mariel Young

Yonatan Cooper

https://pqg2020.slack.com/archives/C01D90M2H70

 

honorable mention8. Identification of common regulatory variants underlying tauopathies using massively parallel reporter assays

Yonatan Cooper, Giovanni Coppola, Dan Geschwind

Nicholas Darci-Maher

https://pqg2020.slack.com/archives/C01DFU7A3RR

9. Cross-tissue omics analysis between adipose tissue and liver identifies novel serum biomarker candidates for non-alcoholic fatty liver disease

Nicholas Darci-Maher, Marcus Alvarez, David Z Pan, Zong Miao, Dorota Kaminska, Jussi Pihlajamäki, Päivi Pajukanta

Aimee Deaton

https://pqg2020.slack.com/archives/C01DFUQE08K

10. Gene-level analysis of loss of function variants in 246,730 whole exome sequences reveals an association of GIGYF1 with diabetes

Aimee M. Deaton, Margaret M. Parker, Lucas D. Ward, Alexander O. Flynn-Carroll, Lucas BonDurant, Gregory Hinkle, Paul Nioi

Kushal Dey

https://pqg2020.slack.com/archives/C01DG04FQ91

11. Disease-critical cell types and cellular processes across the human body

Kushal K Dey, Karthik A Jagadeesh, Daniel Montoro, Jesse Engreitz, Ramnik Xavier, Alkes Price, Aviv Regev

Mulong Du

https://pqg2020.slack.com/archives/C01D95ZV80N

12. Evidence from large-scale population supporting the causal cascade of CYP26A activity, smoking dose, and lung cancer risk

Mulong Du, Qianyu Yuan, Zhengdong Zhang, Guoshuai Cai, Qingyi Wei, Philip Lazarus, David C. Christiani

Diptavo Dutta

https://pqg2020.slack.com/archives/C01DT44LBKM

13. Aggregative trans-eQTL associations detect trait-specific target gene sets

Diptavo Dutta, Yuan He, Ashis Saha, Marios Arvanitis, Alexis Battle, Nilanjan Chatterjee

Esther Herrera-Luis

https://pqg2020.slack.com/archives/C01DCQWM61K

14. Admixture mapping analysis of asthma exacerbations in African Americans

Esther Herrera-Luis, Fabian Lorenzo-Diaz, Angel C. Y. Mak, Esteban G. Burchard, Maria Pino-Yanes

Ruth Johnson

https://pqg2020.slack.com/archives/C01E5NWA8BA

 

honorable mention15. Fine-scale estimates of regional polygenicity provide insights into the genetic architecture of complex traits

Ruth Johnson, Kathryn Burch, Kangcheng Hou, Bogdan Pasaniuc*, Sriram Sankararaman*

Pavel Kuksa

https://pqg2020.slack.com/archives/C01E5NWUV7A

16. SparkINFERNO: next-generation high-throughput pipeline for inferring molecular mechanisms of non-coding genetic associations

Pavel P. Kuksa, Chien-Yueh Lee, Prabhakaran Gangadharan, Otto Valladares, Yuk Yee Leung, Li-San Wang

Seung Hyuk (Tony) Lee

https://pqg2020.slack.com/archives/C01D96278BG

17. Abdominal obesity GWAS variants regulate adipose cell-type signature genes

Seung Hyuk (Tony) Lee, Marcus Alvarez, David Z. Pan, Uma Thanigai Arasu, Tiit Örd, Dorota Kaminska, Sini Heinonen, Kirsi H Pietiläinen, Minna U Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta

Jimmy Tsz Hang Lee

https://pqg2020.slack.com/archives/C01DS7LGRGV

18. Fast searches of single cell datasets by variant and trait

Jimmy Tsz Hang Lee, Nikolaos Patikas, Vladimir Yu Kiselev, Martin Hemberg

Jiajin Li

https://pqg2020.slack.com/archives/C01E6C5CPK6

19. Rare variants regulate expression of nearby individual genes in multiple tissues

Jiajin Li, Nahyun Kong, Buhm Han, Jae Hoon Sul

Xihao Li

https://pqg2020.slack.com/archives/C01D9632806

20. Scalable rare variant meta-analysis of whole genome sequencing studies using summary statistics and functional annotations

Xihao Li, Zilin Li, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor, Han Chen, Jerome I. Rotter, Cristen J. Willer, Pradeep Natarajan, Gina M. Peloso, and Xihong Lin, on behalf of the TOPMed Lipids Working Group, BioData Catalyst Consortium

Zilin Li

https://pqg2020.slack.com/archives/C01DN2YDPT6

21. A Framework for Detecting Noncoding Associations in Large-Scale Whole Genome Sequencing Studies

Zilin Li, Xihao Li, Hufeng Zhou, Sheila M. Gaynor, Margaret Sunitha, Akhil Pampana, Jerome I. Rotter, Cristen J. Willer, Gina M. Peloso, Pradeep Natarajan and Xihong Lin, on behalf of the TOPMed Lipids Working Group

Chen Mo

https://pqg2020.slack.com/archives/C01DUGQESSD

22. Genetic Fine-mapping via Learning Graph Structures of Linkage Disequilibrium Patterns

Chen Mo, Zhenyao Ye, Tianzhou Ma, Shuo Chen

Achal Patel

https://pqg2020.slack.com/archives/C01DFTM1NDQ

23. Differential germline associations with risk of recurrence scores in White and Black breast cancer patients

A. Patel, A. Bhattacharya, M.I. Love, M.A. Troester

Wouter Peyrot

https://pqg2020.slack.com/archives/C01D965JG2J

24. Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

W.J. Peyrot, A.L. Price

Jialin Qu

https://pqg2020.slack.com/archives/C01DFTNN92N

25. Gene set analysis with graph embedded kernel association test

Jialin Qu and Yuehua Cui

Brody Receveur

https://pqg2020.slack.com/archives/C01DVCL2XDY

26. Computationally efficient, exact, multimarker omnibus tests by leveraging individual marker summary statistics from large biobanks

Angela Zigarelli, Hanna Venera, Brody Receveur, Jack Wolf, Jason Westra, and Nathan Tintle

Alexandria Szalanczy

https://pqg2020.slack.com/archives/C01DFTP165Q

27. Verification of Keratinocyte-Associated Protein 3 as a Novel Gene for Adiposity

Alexandria M Szalanczy, Osborne Seshie, Emily Goff, Michael Grzybowski, Aron M Geurts, & Leah C Solberg Woods

Ming-Ju Tsai

https://pqg2020.slack.com/archives/C01E1GWQFSQ

28. Identifying critical downstream gene targets associated with osteoporosis via gene regulatory landscapes

Ming-Ju Tsai, Sjur Reppe, Tadatoshi Sato, Richard Gill, Wein, Marc N, Kaare Gautvik, Yi-Hsiang Hsu

Yi Zhang

https://pqg2020.slack.com/archives/C01E5C50PED

29. A Breast Cancer-Associated Genetic Variant Modulates Immune Cells in the Tumor Microenvironment

Yi Zhang, Mohith Manjunath, Jialu Yan, Brittany A. Baur, Shilu Zhang, Sushmita Roy, Jun S. Song

Session II: From causal genes and pathways to drug discovery and pharmacogenetics

 

Presenter & Slack Link Poster Number, Title, & Authors
Rupam Bhattacharyya

https://pqg2020.slack.com/archives/C01DN26P02Y

30. TransPRECISE: Proteomics-based Network Modeling of the Pan-cancer Patient and Cell Line Interactome

Rupam Bhattacharyya, University of Michigan; Min Jin Ha, The University of Texas MD Anderson Cancer Center; Qingzhi Liu, University of Michigan; Rehan Akbani, The University of Texas MD Anderson Cancer Center; Han Liang, The University of Texas MD Anderson Cancer Center; Veerabhadran Baladandayuthapani, University of Michigan.

Beverly Dosso

https://pqg2020.slack.com/archives/C01DN2SEXFE

31. ELOVL SNPs impact response to PUFA-rich diets and patient outcomes in secondary analysis of OMEGA trial

Beverly Dosso, Susan Sergeant, D. Clark Files, Timothy D. Howard, Carl D. Langefeld, Floyd H. Chilton, and Elaheh Rahbar

Chachrit Khunsriraksakul

https://pqg2020.slack.com/archives/C01DN32EK28

 

honorable mention32. PUMICE- Prediction Using Models Informed by Chromatin conformations and Epigenomics

 

Chachrit Khunsriraksakul, Daniel McGuire, Renan Sauteraud, Fang Chen, Lina yang, Rosa Kim, Jordan Hughey, Scott Eckert, J. Dylan Weissenkampen, Dajiang J. Liu

Camila Lopes-Ramos

https://pqg2020.slack.com/archives/C01DL0T6FE2

33. Regulatory networks of liver carcinoma reveal sex-specific patterns of gene regulation

Camila M. Lopes-Ramos, Marieke L. Kuijjer, Kimberly Glass, Dawn L. DeMeo, John Quackenbush

Sinha Rileen

https://pqg2020.slack.com/archives/C01DY1ZEWLA

34. Multi-omics Verification of Patient-Derived Tumor Models

Rileen Sinha, Amir Vajdi Hoojghan, Elizabeth Cohen, Aniket Shetty, Smitha Yerrum, Kin-Hoe Chow, Keith L Ligon, Michael Y. Tolstorukov

Session III: Polygenic scores for disease prevention and clinical action

Presenter & Slack Link Poster Number, Title, & Authors
Sofía Aguilar Lacasaña

https://pqg2020.slack.com/archives/C01E5P4P308

35. Polygenic Risk for ADHD and ASD and their relationship with cognitive measures in school children

Sofía Aguilar-Lacasaña, Natalia Vilor-Tejedor, Philip Jansen, Mònica López-Vicente, Mariona Bustamante, Miguel Burgaleta, Jordi Sunyer, Silvia Alemany

James Fife

https://pqg2020.slack.com/archives/C01E89E65H7

36. Assessing clinical risk using polygenic risk and monogenic variants

James Fife, Christopher Cassa

Ruchi Chaudhary

https://pqg2020.slack.com/archives/C01DVHC385Q

37. High polygenic risk and strong recessive disease inheritance in a young-onset Parkinson’s disease cohort in India

Ruchi Chaudhary

Patricia Genius

https://pqg2020.slack.com/archives/C01DENTCVEK

38. Differentially genetic susceptibility of Hippocampal Subfields Volumes: A Polygenic-wide Association Study

Patricia Genius, Greg Operto, Tavia E. Evans, Carles Falcón, Carolina Minguillón, Karine Fauria, Hieab H. Adams, Roderic Guigó, Juan Domingo Gispert, Natalia Vilor-Tejedor, and for the ALFA study

Natalie Hasbani

https://pqg2020.slack.com/archives/C01DRAFDABG

39. Lifetime risk of coronary heart disease: American Heart Association’s Life’s Simple 7 lifestyle recommendations and polygenic risk

Natalie R. Hasbani, Symen Ligthart, Michael R. Brown, Adam Heath, Allison Bebo, Kellan E. Ashley, Eric Boerwinkle, Alanna C. Morrison, Aaron Folsom, David Aguilar, Paul S. de Vries

Jie Huang

https://pqg2020.slack.com/archives/C01DF0HEHB9

40. PAGEANT (Personal Analysis of GEnome and ANnotation Toolkit)

Jie Huang, Dan King

Xiaoqi Li

https://pqg2020.slack.com/archives/C01EBKMPAUR

41. Polygenic Risk Assessment: Genetics Supported Imaging Diagnosis for Parkinson’s Disease

Xiaoqi Li, Miguel Renteria, Xianjun Dong

Fah Sathirapongsasuti

https://pqg2020.slack.com/archives/C01EBKUPJJD

 

42. South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine

Jeffrey D. Wall*, J. Fah Sathirapongsasuti*, Ravi Gupta*, Ramesh Menon, Saurabh Belsare, Sameer Phalke, Anamitra Barik, Rajesh Kumar Rai, Anu Mittal, John Fang, Deepak Tanneeru, Jacqueline Robinson, Ruchi Chaudhary, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Radha Venkatesan, Wallace Wang, Asif Rasheed, Pui-Yan Kwok, Amit Khera, Lakshmi, Adam Butterworth, John Danesh, Arkasubhra Ghosh, Viswanathan Mohan, Partha P. Majumder, Danish Saleheen, Abhijit Chowdhury, Sekar Seshagiri, Eric Stawiski, Andrew Peterson

Magdalena Sevilla-Gonzales

https://pqg2020.slack.com/archives/C01DSL4KE4V

43. Effect of fasting insulin-associated gene variant clusters on cardiometabolic outcomes

Magdalena Sevilla-Gonzalez, Hyunkyung Kim, Sarah Hsu, Jordi Merino, James B. Meigs, Jerome Rotter, Mark O. Goodarzi, Alisa K. Manning, Miriam Udler

Sarah Urbut

https://pqg2020.slack.com/archives/C01E858JUMP

44. Understanding the Genetic Effects on Multivariate Lipid Phenotypes: An exploration of the Million Veterans Project Resource

Sarah Urbut, S.Margaret Sunitha, Akhil Pampana, Lily Dattillo, Ben Neale, Chris O’Donnell, Gina Peloso, Pradeep Natarajan

Zhi Yu

https://pqg2020.slack.com/archives/C01DSJ6NYKX

45. Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases: the Atherosclerosis Risk in Communities Study

Zhi Yu, Jin Jin, Adrienne Tin, Anna Köttgen, Bing Yu, Jingsha Chen, Aditya Surapaneni, Linda Zhou, Christie M. Ballantyne, Ron C. Hoogeveen, Dan E. Arking, Nilanjan Chatterjee, Morgan E. Grams, Josef Coresh

Zijie Zhao

https://pqg2020.slack.com/archives/C01EGJKJ9Q8

46. Robust fine-tuning of diverse polygenic risk score models using GWAS summary statistics

Zijie Zhao; Yanyao Yi; Jie Song; Yuchang Wu; Xiaoyuan Zhong; Yupei Lin; Timothy J. Hohman; Jason Fletcher; Qiongshi Lu