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Department of Epidemiology

677 Huntington Avenue
Kresge Building 9th Floor
Boston, MA 02155
Phone: 617.432.1050

Other Affiliations

Professor, Erasmus University Medical School, The Netherlands

Publications

Meurs JB van, Dhonukshe-Rutten RA, Pluijm SM, Klift M van der, Jonge R de, Lindemans J, Groot LC de, Hofman A, Witteman JC, Leeuwen JP van, Breteler MM, Lips P, Pols HA, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350:2033-41.

Schuit SC, Oei HHS, Witteman JCM, Geurt van Kessel CH, Meurs JBJ van, Nijhuis RL, Leeuwen JPTM van, Jong FH de, Zillekens MC, Hofman A, Pols HAP, Uitterlinden AG. Estrogen receptor ?? gene polymorphisms and risk of myocardial infarction. JAMA 2004;291:2969-71.

Tiemeier H, Dijck W van, Hofman A, Witteman JCM, Stijnen T, Breteler MMB. Relationship between atherosclerosis and late-life depression. The Rotterdam Study. Arch Gen Psychiatry 2004;61:369-76.

Meer IM van der, Bots ML, Hofman A, del Sol AI, Kuip DA van der, Witteman JC. Predictive value of non-invasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 2004;109:1089-94.

Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348:1215-22.

Geerlings MI, Launer LJ, de Jong FH, Ruitenberg A, Stijnen T, van Swieten JC, Hofman A, Witteman JC, Pols HA, Breteler MM. Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Ann Neurol 2003;53:607-15.

Croes EA, Dermaut B, Houwing-Duistermaat JJ, Van den Broeck M, Cruts M, Breteler MM, Hofman A, van Broeckhoven C, van Duijn CM. Early cognitive decline is associated with prion protein codon 129 polymorphism. Ann Neurol 2003;54:275-6.

Schoofs MW, van der Klift M, Hofman A, de Laet CE, Herings RM, Stijnen T, Pols HA, Stricker BH. Thiazide diuretics and the risk for hip fracture. Ann Intern Med 2003;139:476-82.

Leeuwen R van, Vingerling JR, Hofman A, Jong PT de, Stricker BH. Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement. BMJ 2003;326:255-6.

Hollander M, Bots ML, Iglesias del Sol A, Koudstaal PJ, Witteman JCM, Grobbee DE, Hofman A, Breteler MMB. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asympotomatic elderly: the Rotterdam Study. Circulation 2002;105:2872-7.

Engelhart MJ, Geerlings MI, Ruitenberg A, Swieten JC van, Hofman A, Witteman JCM, Breteler MMB. Dietary intake of antioxidants and risk of Alzheimer??s disease: the Rotterdam Study. JAMA 2002;287:3223-9.

Ruitenberg A, Swieten JC van, Witteman JCM, Mehta KM, Duijn CM van, Hofman A, Breteler MMB. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet 2002;359:281-6.

Veld BA in ‘t, Ruitenberg A, Hofman A, Launer LJ, Duijn CM van, Stijnen T, Breteler MMB, Stricker BHC. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med 2001;345:1515-21.

Groot JC de, Leeuw F-E de, Oudkerk M, Gijn J van, Hofman A, Joiles J,Breteler MMB. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol 2000;47:145-51.

Salas M, Hofman A, Stricker BHCh. Confounding by indication: an example of variation in the use of epidemiologic terminology. Am J Epidemiol 1999;149:981-3.

Witteman JCM, D’Agostino RB, Stijnen Th, Kannel WB, Cobb JC, Ridder MAJ de, Hofman A, Robins JM. G-estimation of causal effects: isolated systolic hypertension and cardiovascular death in the Framingham Heart Study. Am J Epidemiol 1998;148:390-401.

Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FEA, Grant SFA, Hofman A, Leeuwen JPTM van, Pols HAP, Ralston SH. Relation of alleles of the collagen type 11 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 1998;338:1016-21.

Ott A, Slooter AJC, Hofman A, Harskamp F van, Witteman JCM,Broeckhoven C Van, Duijn CM van, Breteler MMB. Smoking and risk of dementia and Alzheimer’s disease in a population-based cohort study: the Rotterdam Study. Lancet 1998;351:1840-3.

Duijn CM van, Delasnerie-Laupr??tre N, Masullo C, Zerr I, Silva R de, Wientjes DPWM, Brandel J-P, Weber T, Bonavita V, Zeidler M, Alp??rovitch A, Poser S, Granieri E,Hofman A, Will RG, for the European Union (EU) Collaborative Study Group of Creutzfeldt-Jakob disease (CJD). Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95. Lancet 1998;351:1081-5.

Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, Harskamp F van, Duijn CM van, Broeckhoven C van, Grobbee DE. Atherosclerosis, apolipoprotein and prevalence of dementia and Alzheimer’s disease. The Rotterdam Study. Lancet 1997;349:151-4.

Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alprovitch A, Poser S, Pocchari M, Hofman A, Smith PG. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996;347:921-5.

Hoes AW, Grobbee DE, Lubsen J, Man in t Veld AJ, Does E van der, Hofman A. Diuretics, -blockers, and the risk for sudden cardiac death in hypertensive patients. Ann Intern Med 1995;123:481-7.

Duijn CM van, Knijff P de, Cruts M, Wehnert A, Havekes LM, Hofman A, Broeckhoven C van. Apolipoprotein E4 allele in a population based study of early onset Alzheimer’s disease. Nature Genet 1994;7:74-9.

ASPECT Research Group. The effect of long-term anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction. Lancet 1994;343:499-504.

Witteman JCM, Grobbee DE, Valkenburg HA, Hemert van AM, Stijnen T, Hofman A. Cigarette smoking and the development and progression of aortic atherosclerosis; A 9 year population-based follow-up study in women. Circulation 1993;88:2156-62.

Bots ML, Swieten JC van, Breteler MMB, Jong PTVM de, Gijn J van, Hofman A, Grobbee DE. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet 1993;341:1232-7.

Hendriks L, Duijn CM van, Cras P, Cruts M, Hul W van, Harskamp van F, Warren A, Innis Mc MG, Antonara SE, Martin JJ, Hofman A, Broeckhoven C van. Presenile-dementia and cerebral-hemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene. Nature Genet 1992;1:218-21.

Hooft IMS van,Grobbee DE,Derkx FHM, Leeuw PW de,Schalekamp MADH,Hofman A. Renal hemodynamics and the renin-angiotensin-aldosterone system in the early phase of primary hypertension. N Engl J Med 1991;324:1305-11.

Hofman A, Grobbee DE, Jong PTVM de, Ouweland FA van den. Determinants of disease and disability in the elderly: the Rotterdam Study. Eur J Epidemiol 1991;7:403-22.

Bruining GJ, Grobbee DE, Scheffer GJ, Bruijn AM de, Molenaar JL, Hofman A, Bruining HA, Valkenburg HA. Ten-year follow-up study of islet-cell antibodies and childhood diabetes mellitus. Lancet 1989;i:1100-3.

Walter HJ, Hofman A, Vaughan RD, Wynder E. Modification of risk factors for coronary heart disease. Five-year results of a school-based intervention trial. N Engl J Med 1988;318:1093-100.

Grobbee DE, Hofman A. Calcium supplementation lowers diastolic blood pressure in young people with mild hypertension. Lancet 1986;2:703-7.

Hofman A, Valkenburg HA. Determinants of change in blood pressure during childhood. Am J Epidemiol 1983;117:735-43.

Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA 1983;250:370-3.