ahouidi

Ambroise Ahouidi

Fogarty Fellow

Department of Immunology and Infectious Diseases

665 Huntington Ave, Bldg 1, Rm 703
c/o Wirth Lab
Boston, MA 02115

 

Research

Ambroise is a PhD student at Cheikh Anta Diop University (Senegal) in the Department of Microbiology. He conducts research in the laboratory of Professor Souleymane Mboup at Le Dantec Hospital. Ambroise conducted his Masters dissertation research in the laboratory of Professor Mboup studying viral diagnostic techniques and evaluating HIV rapid test efficacy. As a PhD student, Ambroise has studied P. falciparum merozoite invasion and immune mediated mechanisms of invasion inhibition in Senegal, The Gambia, and Boston as a Fogarty trainee with Professor Dyann Wirth. Ambroise identified a large genetic deletion in a major invasion ligand—PfRh2b—in Senegal and has been studying the impact of this deletion on invasion pathway and immune mediated invasion inhibition. Ambroise’s work is multidisciplinary and he has combined approaches in molecular biology with population genetics, epidemiology, and immunology to study the dynamics of polymorphisms in important Plasmodium falciparum invasion ligands in global parasite populations.

Publications

Ahouidi A and Jennings CV, ZilversmitM, BeiA, RaynerJ, SarrO, NdirO, WirthD, Mboup S, Duraisingh M. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infection and Immunity. 2007

Sarr O, Ahouidi A, Daily J, Ndiaye D, Ndir O, Mboup S, Wirth D. Mutations in Pfcrt K76T do not correlate with Sulfadoxine-pyrimethamine amodiaquine failure in Pikine, Senegal. Parasitol Res. 2008.

Paul M. Lantos, Ambroise Ahouidi, Cameron Jennings, Amy Bei, Tiffany DeSimone, Ousmann, Sarr, Omar Ndir, Souleymane Mboup, Dyann Wirth, Manoj Duraisingh. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitol Res 2008.

Ambroise Ahouidi, Amy K. Bei, Dan Neafsey, Ousmane Sarr, Sarah Volkman, Terrie Taylor, Janet Cox-Singh, Balbir Singh, Marcello Ferreira, Omar Ndir, Zul Premji, Souleymane Moup and Manoj T. Duraisingh. Population genetic analysis of dimorphic vaccine candidates of Plasmodium falciparum. Infection Genetics and evolution 2010.

Amy K. Bei,Tiffany M. DeSimone, Aida S. Badiane, Ambroise D. Ahouidi, Tandakha Dieye, Daouda Ndiaye, Ousmane Sarr, Omar Ndir, Souleymane Mboup, and Manoj T. Duraisingh. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium Falciparum  Am. J. Hematol 2010.     

Education

B.S., 1993, Valdiodio Ndiaye College, Kaolack
M.S., 1999, Cheikh Anta Diop University, Dakar
Ph.D., Pending, Cheikh Anta Diop University, Dakar