Harvard Catalyst Biostatistics Journal Club – 6/27

Harvard Catalyst Biostatistics Journal Club
“Issue of Multiple Comparisons”
Wednesday, June 27  |  1:00pm – 2:00pm
MGH Biostatistics Center, 50 Staniford Street, Suite 560
David Schoenfeld, PhD, Professor of Medicine at Harvard Medical School and MGH, and Professor in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health, will lead the June meeting of the Harvard Catalyst Biostatistics Journal Club. He will discuss the issue of multiple comparisons which come up constantly in Harvard Catalyst consultations. It is particularly vexing because clients often do not have an adequate sample size to apply a Bonferroni correction and they have multiple endpoints, treatment groups, and hypotheses. This paper argues that in many situations these corrections are not required. The group will discuss whether or not they agree with the authors’ recommendations.

Dr. Schoenfeld will present the following article: “Multiplicity Considerations in the Design and Analysis of Clinical Trials” by Richard J. Cook and Vern T. Farewell in Journal of the Royal Statistical Society. Series A (Statistics in Society), Vol. 159, No. 1 (1996), pp. 93-110, DOI: 10.2307/2983471. Of course, in addition to the main articles, you are also highly encouraged to read any supplementary articles of your choosing. 

*Call-in numbers and contact information will follow shortly