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HIV Working Group

September 24 @ 1:00 pm - 1:50 pm

HIV Working Group Flyer for Sept 24

Michael Hughes, Ph.D.
Professor, Department of Biostatistcs, Harvard T.H. Chan School of Public Health
Director, Center for Biostatistics in AIDS Research

Design Considerations in a COVID-19 Platform Trial — Experience from the ACTIV-2 Trial

Abstract: ACTIV-2 is a major international platform trial led by the NIH-funded AIDS Clinical Trials Group. It was designed in response to the COVID-19 pandemic and has evaluated several candidate agents for the treatment of non-hospitalized people with symptomatic COVID-19, with the aim of reducing hospitalizations and deaths. The design incorporates novel design features including the sharing of placebo control groups, potentially with different placebos for each candidate agent, and a seamless transition from phase 2 to phase 3 evaluation. I will discuss the design and implementation of this complex trial.


September 24
1:00 pm - 1:50 pm