Patrick Emedom-NnamdiDoctoral Student, Department of Biostatistics, Harvard University"Determining Surgical Recovery Strategies with Offline Reinforcement Learning"ABSTRACT: mproving patient recovery after a post-operative event continues to be a concern for many medical providers. We propose using offline reinforcement learning algorithms to identify how patients should adapt levels of physical activity and mobility at various post-operative time points … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Alejandra Avalos Title: Factor regression for dimensionality reduction and data integration techniques with applications to cancer data Abstract: Two key challenges in modern statistical applications are the large amount of information recorded per individual, and that such data are often not collected in batches. These batch effects (BE) can be complex, causing distortions in both … Continue reading "Biostat Student Seminar"
Jane LiangDoctoral Student, Department of Biostatistics, Harvard University"Multi-gene, Multi-cancer Mendelian Risk Assessment" ABSTRACT: Risk evaluation to determine individuals who are at greater risk of cancer as a result of heritable mutations is a valuable component of individualized clinical management. Mendelian models identify those at high risk for carrying a pathogenic mutation and assess future risk … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Peter Gilbert, Ph.DProfessor, Vaccine and Infectious Disease/Public Health Sciences Divisions of the Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington"Assessing Immunological Biomarker Surrogate Endpoints in COVID-19 Vaccine Efficacy Trials" ABSTRACT: An objective of phase 3 preventive COVID-19 vaccine efficacy trials is to assess post-vaccination immunological biomarkers as various types of “immune … Continue reading "HIV Working Group"
Each virtual event features 4 rounds of 5-minute talks by department faculty & postdocs. This is a great opportunity to get a quick snapshot of current department research in a relaxed, social setting.
Andy ShiDoctoral Student, Department of Biostatistics, Harvard University"Multiple Phenotype—Multiple Genotype Testing with Principal Components" ABSTRACT: The increasing popularity of large-scale genetic compendiums has driven a recent interest in (1) testing sets of genotypes against a single phenotype and (2) testing sets of phenotypes against a single genotype. Incorporating the information from these correlated sets of … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Carles Boix PhD CandidateMITRegulatory genomic circuitry of human disease loci by integrative epigenomicsAnnotating the molecular basis of human disease remains an unsolved challenge, as 93% of disease loci are non-coding, and gene-regulatory annotations highly incomplete. Here, we present EpiMap, a compendium of 10,000 epigenomic maps across 800 samples, which we use to define chromatin states, … Continue reading "PQG Working Group"
Tuesday November 10, 2020 1:00PM ET Election Forecasting: How We Succeeded Brilliantly, Failed Miserably, or Landed Somewhere in Between A conversation withAndrew Gelman, Ph.D.Professor of Statistics and Political ScienceColumbia University Moderator: Rafael Irizarry Quick RSVP at https://bit.ly/DSNov10
Jeffrey Miller, Ph.D.Assistant Professor, Department of Biostatistics, Harvard T.H. Chan School of Public Health"Inference in Generalized Bilinear Models" ABSTRACT: Latent factor models are widely used to discover and adjust for hidden variation in modern applications. However, most methods do not fully account for uncertainty in the latent factors, which can lead to miscalibrated inferences such … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Communicating Statistical Findings Effectively A conversation withProfessor Sir David SpiegelhalterChair, Winton Centre for Risk and Evidence CommunicationCentre for Mathematical SciencesAuthor: The Art of Statistics Moderator: Rafael Irizarry RSVP at https://bit.ly/DSNov17
We will have the following four speakers discussing their internship experiences: Andy Shi, Irina Degtiar, Lily Koffman, and Raphaelle Toubiana. (student-only event)
We will have the following four speakers discussing their internship experiences: Andy Shi, Irina Degtiar, Lily Koffman, and Raphaelle Toubiana. (student-only event)
Jemar BatherDoctoral Student, Department of Biostatistics, Harvard University "Racial and Ethnic Disparities in Longitudinal Emotional-Behavioral Functioning Among Youth Born to Women Living with HIV" ABSTRACT: Youth with perinatal HIV exposure have demonstrated high rates of emotional-behavioral problems. Few studies have longitudinally examined racial/ethnic disparities in such functioning across adolescence, a critical time for targeting much-needed … Continue reading "HIV Workiing Group"
Heng Li, Ph.D.Assistant ProfessorBiomedical Informatics, Harvard Medical SchoolBiostatistics and Computational Biology, Dana-Farber Cancer Institute"The Assembly of Human Pangenome" ABSTRACT: The primary GRCh38 assembly represents the genome of a single haplotype and misses thousands of structural variations in each individual. To encode and study these complex variations, we developed hifiasm and minigraph to assemble PacBio high-fidelity … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Gopal KotechaDoctoral Student, Department of Biostatistics, Harvard University"Regulatory Approval Prediction Models" ABSTRACT: Despite improvements in technology, drug discovery has become slower and more expensive over the last few decades, with the cost of developing a new drug roughly doubling every decade. At the same time, there has been a near exponential increase in the number … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Mona Kelkar will present the thesis entitled "Reliability and Validation Study of the Decibel Hearing Test iPhone App". The thesis committee is chaired by Dr. Molin Wang, and includes Dr. Gary Curhan and Dr. Erin Lake.
Michael Hudgens, Ph.DProfessor, Department of Biostatistics, University of North Carolina at Chapel Hill / Director, Biostatistics Core, UNC Center for AIDS Research (CFAR) "Counting Viruses: Estimating the Size of the Latent HIV Reservoir" ABSTRACT: We will discuss statistical methods for quantifying the latent HIV reservoir in anti-retroviral therapy (ART) suppressed individuals. In particular, we will … Continue reading "HIV Working Group"
Each virtual event features 4 rounds of 5-minute talks by department faculty & postdocs. This is a great opportunity to get a quick snapshot of current department research in a … Continue reading "Lightning Talks"