Yann Cormerais

Postdoctoral Fellow: yann

2017 –

Education:

Ph.D., 2016, University of Sophia Antipolis, Nice, France

Research Interest:

Yann is interested in understanding the interconnection between oncogenic pathways and metabolism. He is focused on defining the differential effects of the mTOR complexes on metabolic reprogramming downstream of the PI3K signaling.

Publications:

Cormerais Y, Vucetic M, Pouysségur J. Targeting amino acids transporters (SLCs) to starve cancer cells to death. Biochem Biophys Res Commun. 2019;520(4):691-693. doi:10.1016/j.bbrc.2019.10.173. PMID: 31761081

Daher B, Parks SK, Durivault J, Cormerais Y, Baidarjad H, Tambutté E, Pouyssegur J, Vucetic M. Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses. Cancer Res. 2019 Jun 7. doi: 10.1158/0008-5472.CAN-18-3855. Epub ahead of print. PMID: 31175120

Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019 Feb 19. doi: 10.1111/jcmm.14176. Epub ahead of print. PMID:30784173

Giuliano S, Dufies M, Ndiaye PD, Viotti J, Borchiellini D, Parola J, Vial V, Cormerais Y, Ohanna M, Imbert V, Chamorey E, Rioux-Leclercq N, Savina A, Ferrero JM, Mograbi B, Pagès G. Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5. Theranostics. 2019 Jan 30;9(4):1181-1199. eCollection 2019. PMID: 30867824

Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018; 293(8):2877-2887. Epub 2018 Jan 11. PMID: 29326164

Vučetić M, Cormerais Y, Parks SK, Pouysségur J. The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code. Front Oncol. 2017;7:319. doi: 10.3389/fonc.2017.00319. eCollection 2017. PMID: 29312889

Avinash P, Yann C, Jacques P, Daniela R. Dynamin inhibitors block mTORC1 activation by amino acids independently of dynamin. J Cell Sci. 2018; 131(1). PMID: 29150487

Parks SK, Cormerais Y and Pouysségur J. Hypoxia and cellular metabolism in tumor pathophysiology. J Physiol. 2017; 595(8):2439-2450. Epub 2017 Feb 19. PMID: 28074546

Courtial L, Picco V, Grover R, Cormerais Y, Rottier C, Labbe A, Pagès G, Ferrier-Pagès C. The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells. Sci Rep. 2017; 7:45713. PMID: 28374828

Parks SK, Cormerais Y, Durivault J and Pouyssegur J. Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. Oncotarget. 2017; 8(6):10225-10237. PMID: 28055960

Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016; 76(15):4481-92. PMID: 27302165

Parks SK, Cormerais Y, Marchiq I, Pouyssegur J. Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export. Mol Aspects Med. 2016; 47-48:3-14. PMID: 26724171

Giuliano S, Cormerais Y, Dufies M, Grépin R, Colosetti P, Belaid A, Parola J, Martin A, Lacas-Gervais S, Mazure NM, Benhida R, Auberger P, Mograbi B, Pagès G. Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. Autophagy. 2015; 11(10):1891-904. PMID: 26312386