Dr. Lopes-Ramos is a Research Associate of the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. Her research involves developing and applying genomics and systems biology methods to understand the regulatory processes that contribute to cancer development and response to therapies, including understanding differences between men and women.
During her PhD, she was trained in both experimental biology and bioinformatics to understand the molecular mechanisms associated with treatment response in colorectal cancer, and to identify predictive molecular biomarkers. During her postdoctoral fellowship, she developed skills in computational biology and network science. She has worked in the integration of ‘omics “big data” and the application of network methods to a wide range of problems, including the study of regulatory differences between cell lines and their tissues-of-origin, tissue-specific regulation, and the study of sexual dimorphism in healthy tissues and in colon cancer.
Currently, she is studying sexually dimorphic gene regulatory patterns across multiple cancer types in a “pan-cancer” study. This approach can provide substantial insight into better combined therapies that account for sex differences, and can have a major impact on the development of personalized targeted therapies and cancer discoveries.
- Lopes-Ramos CM, Marieke L Kuijjer, Shuji Ogino, Charles S Fuchs, Dawn L DeMeo, Kimberly Glass, John Quackenbush. Gene regulatory network analysis identifies sex-linked differences in colon cancer drug metabolism. Cancer Res. 2018 in press.
- Lopes-Ramos CM, Paulson JN, Chen CY, Kuijjer ML, Fagny M, Platig J, Sonawane AR, DeMeo DL, Quackenbush J, Glass K. Regulatory network changes between cell lines and their tissues of origin. BMC Genomics. 2017 Sep 12;18(1):723.
- Sonawane AR, Platig J, Fagny M, Chen CY, Paulson JN, Lopes-Ramos CM, DeMeo DL, Quackenbush J, Glass K, Kuijjer ML. Understanding Tissue-Specific Gene Regulation. Cell Rep. 2017 Oct 24;21(4):1077-1088.
- Lopes-Ramos CM, Barros BP, Koyama FC, Carpinetti PA, Pezuk J, Doimo NTS, Habr-Gama A, Perez RO, Parmigiani RB. E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. PLoS One. 2017 Jul 13;12(7):e0181153.
- Lopes-Ramos CM, Habr-Gama A, Quevedo BS, Felício NM, Bettoni F, Koyama FC, Asprino P, Galante PAF, Gama-Rodrigues J, Camargo AA, Perez RO, Parmigiani RB. Overexpression of miR-21-5p as a predictive marker for complete tumor regression to neoadjuvant chemoradiotherapy in rectal cancer patients. BMC Med Genomics. 2014 Dec 11;7:68.