Caroline Buckee

Associate Professor of Epidemiology

Department of Epidemiology

Contact Information

Kresge Building, Office 506E
677 Huntington Avenue
Boston, Massachusetts 02115
cbuckee@hsph.harvard.edu

Background

Dr. Caroline Buckee joined Harvard School of Public Health in the summer of 2010 as an Assistant Professor of Epidemiology, and was promoted to Associate Professor in 2017.  In 2013, Dr. Buckee was named the Associate Director of the Center for Communicable Disease Dynamics.

The Buckee lab uses mathematical models and data science to understand the mechanisms driving the spread of infectious diseases, with a focus on pathogens like malaria that effect vulnerable populations in low income countries. After receiving a D.Phil from the University of Oxford, Caroline worked at the Kenya Medical Research Institute to analyze clinical and epidemiological aspects of malaria as a Sir Henry Wellcome Postdoctoral Fellow. Her work led to an Omidyar Fellowship at the Santa Fe Institute, where she developed theoretical approaches to understanding malaria parasite evolution and ecology. In 2013 Dr. Buckee was named one of MIT Tech Review’s 35 Innovators Under 35, a CNN Top 10: Thinker, and Foreign Policy Magazine’s Global Thinkers. Her work has appeared in high profile scientific journals such as Science and PNAS, as well as being featured in the popular press, including CNN, The New Scientist, Voice of America, NPR, and ABC.

Research

Dr. Buckee’s group uses a range of mathematical models, experimental and pathogen genomic data, and “Big Data” from mobile phones and satellites to understand how human pathogens spread and may be controlled. A major focus of the group is the human malaria parasite, Plasmodium falciparum, which is still a major global killer of children under 5 years. Dr. Buckee’s work spans both the within-host processes that determine pathogenesis in individual hosts, and the population processes that sustain transmission and disease, working with vector biologists to understand the impacts of novel vector control approaches, and with mobile phone operators to track the migration patterns of people that import infections and drug resistant parasites when they travel. Dr. Buckee’s group is also interested in how to predict and contain the spatial spread of emerging epidemics.

Selected recent publications

Taylor et al. (2017) Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent. PLoS Genetics. 13(10):e1007065.

Peak et al. (2017) Comparing nonpharmaceutical interventions for containing emerging epidemics. PNAS. 114(15):4023-4028.

Childs et al. (2016) Disrupting Mosquito Reproduction and Parasite Development for Malaria Control. PLoS Pathogens. 12(12):e1006060.

Wesolowski et al. (2015) Quantifying seasonal population fluxes driving rubella transmission dynamics using mobile phone data. PNAS. 112(35):11114-9.

Larremore et al. (2015) Ape parasite origins of human malaria virulence genes. Nat. Comm. 6:8368.

Wesolowski et al. (2015) Impact of human mobility on the emergence of dengue epidemics in Pakistan. PNAS. 112(38):11887-92.

Lim et al. (2013) Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat. Comm. 4:1638

Wesolowski et al. (2012) Quantifying the Impact of Human Mobility on Malaria. Science. 338(6104):267-70.