Chongzhi Zang

Research Fellow

Department of Biostatistics

Department of Biostatistics

DFCI Biostatistics & Computational Biology
44 Binney Street
Boston, Massachusetts 02115


B.S., Physics, 2005, Peking University

Ph.D., Physics, 2010, The George Washington University


My research interests focus on developing computational and statistical methods for analyzing high-throughput genomic data (e.g. ChIP-Seq) and integrative modeling with omics data to study chromatin dynamics and epigenetic regulation of gene expression.


(* indicates equal contributions)

  • Hao Z, Zhang J, Yu J, Zhang Z, Zhong J, Zang C, Jin Z, Wang Z, Wei Z. (2006). Fluorescence measurement and acoustic diagnostics of plasma channels in air. Acta Physica Sinica 55, 299-303.
  • Wang Z*, Zang C*, Rosenfeld JA*, Schones DE, Barski A, Cuddapah S, Cui K, Roh TY, Peng W, Zhang MQ, Zhao K. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nature Genetics 40, 897-903. PMCID: PMC2769248
  • Cui K*, Zang C*, Roh TY, Schones DE, Childs RW, Peng W, Zhao K. (2009). Chromatin signatures in multipotent hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4, 80-93. PMCID: PMC2785912
  • Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O’Shea JJ, Zhao K. (2009). Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167. PMCID: PMC2722509
  • Zang C, Schones DE, Zeng C, Cui K, Zhao K, Peng W. (2009). A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics 25, 1952-1958. PMCID: PMC2732366
  • Araki Y, Wang Z, Zang C, Wood WH, Schones D, Cui K, Roh TY, Lhotsky B, Wersto RP, Peng W, Becker KG, Zhao K, Weng NP. (2009). Genome-wide analysis of histone methylations reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity 30, 912-925. PMCID: PMC2709841
  • Jin C*, Zang C*, Wei G, Cui K, Peng W, Zhao K, Felsenfeld G. (2009). H3.3/H2A.Z double variant-containing nucleosomes mark ‘nucleosome-free regions’ of active promoters and other regulatory regions. Nature Genetics 41, 941-945. PMCID: PMC3125718
  • Wang Z*, Zang C*, Cui K*, Schones DE, Barski A, Peng W, Zhao K. (2009). Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138, 1019-1031. PMCID: PMC2750862
  • Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O’Shea JJ, Kanno Y. (2010). Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation. Immunity 32, 840-851. PMCID: PMC2904651
  • Daniel JA, Santos MA*, Wang Z*, Zang C*, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A. (2010). PTIP promotes chromatin changes critical for immunoglobulin switch recombination. Science 329, 917-923. PMCID: PMC3008398