Professor in the Departments of Nutrition and Global Health and Population
300 Longwood Avenue
Boston Children’s Hospital – Center for Nutrition
Boston, Massachusetts 02115
BA, 1983, Dartmouth College
MD, 1987, Johns Hopkins University School of Medicine
MPH, 1994, Harvard University School of Public Health
Professor of Pediatrics, Harvard Medical School
Director, Center for Nutrition, Boston Children’s Hospital
My major research interests include:
- the nutritional management of acute and persistent diarrhea,
- micronutrient trials in developing countries to prevent diarrhea and respiratory infections,
- the definition of biomarkers of environmental enteric dysfunction, and
- general aspects of energy and protein metabolism in catabolic diseases.
My colleagues and I have performed studies evaluating the formulation and effectiveness of oral rehydration solutions (ORS) for the treatment of acute diarrhea. In several resource poor settings, we have performed clinical trials of ORS, the results of one such study resulting in the first significant change in the composition of ORS since its inception in the late 1960’s. In collaboration with colleagues at HSPH and Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania, we are evaluating the efficacy of micronutrient supplementation in infants and young children born to women with or at risk of HIV infection. With colleagues at St John’s Research Institute in Bangalore, India, we are evaluating the effects of maternal vitamin B12 supplementation on biochemical and clinical parameters during and after pregnancy. Also at St. John’s, we are expanding educational efforts in Nutrition at the undergradute and graduate level.
In both developing and industrialized countries, we have completed studies on the micronutrient status of children, including those with cystic fibrosis, malaria, undernutrition, and intestinal failure. We are applying state of the art nutritional assessment techniques (e.g., stable isotopes, indirect calorimetry, body composition methodologies) to patients with a variety of catabolic illnesses, including HIV/AIDS, inflammatory bowel disease, intestinal failure and cancer.
In addition to my global health research interests, I am a pediatric gastroenterologist and nutrition physician at Boston Children’s Hospital where I direct the Center for Nutrition. I am Medical Director of the Center for Advanced Intestinal Rehabilitation, one of the largest centers in the US for the care of children with intestinal failure/chronic diarrhea syndromes. I am the course co-director of the Harvard College course “Nutrition and Global Health” and mentor undergraduate, graduate and post-doctoral students at HMS and HSPH.