Adjunct Professor of Immunology and Infectious Diseases
Mission – This laboratory focuses on understanding the molecular basis of organelle stress and its relationship to pathological conditions affecting the nervous system, and the development of prototypic therapies to prevent this damage. Our laboratory is committed to the study of cellular strategies involved in adaptation to chronic endoplasmic reticulum (ER) stress. The ER has important cellular functions, highlighting its role as sophisticated machinery for protein folding and secretion. ER stress engages an integrated signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to cell death processes remain unknown and is a central subject of our research. We are currently developing a systematic approach to underscore the effects of targeting the UPR in several brain diseases involving protein misfolding using genetic manipulation of the pathway in mouse models in addition to develop gene therapy strategies to alleviate ER stress. Our laboratory is one of the most productive laboratories in Chile and currently funded by various national and international organizations.see www.hetzlab.clIn addition we are part of the Biomedical neuroscience Institute as a co-Director and Principal investigator, a multidisciplinary center for neuroscience that bridges 11 different laboratories (www.bni.cl). We also stablished the Neurounion Biomedical Foundation, the first non-profit private Foundation for biomedical research (www.neurounion.com).
07/11-present HARVARD SCHOOL OF PUBLIC HEALTH BOSTON, USA. Department of Immunology and Infectious Diseases. Adjunct Professor
07/11- present UNIVERSITY OF CHILE, SANTIAGO, CHILE. Deputy Director, Biomedical Neuroscience Institute
03/10- present UNIVERSITY OF CHILE, SANTIAGO, CHILE. Full Professor and Principal Investigator. Institute of Biomedical Sciences
01/07- 03/10 UNIVERSITY OF CHILE, SANTIAGO, CHILE. Assistant Professor and Principal Investigator. Institute of Biomedical Sciences
08/05-12/07 HARVARD SCHOOL OF PUBLIC HEALTH BOSTON, USA. Department of Immunology and Infectious Diseases. Postdoctoral Research Fellow. Regulation of the Unfolded Protein Response in the CNS. Advisor: Laurie H. Glimcher, M.D.
08/04-08/05 DANA-FARBER CANCER INSTITUTE, BOSTON, USA. Department of Cancer Immunology & AIDS. Postdoctoral Research Fellow. Regulation of apoptosis by the BCL-2 protein family. Advisor: Stanley Korsmeyer, M.D.
03/00-07/04 SERONO PHARMACEUTICAL RESEARCH INST. GENEVA, SWITZERLAND, Department of Neurobiology and University of Chile. PhD. In Biomedical Sciences. Advisor: Claudio Soto, Ph.D.
2014 Selected by the LatinAmericanScience.Org and Qué Pasa magazine as one of the 30 more influencing scientist in Latin America.