Soon after the introduction of penicillin in the early 1940s, penicillin-resistant S. aureus emerged clinically. Now, more than 70 years later, penicillin susceptible S. aureus still cause clinical infections.Similar patterns have been observed for each of the anti-staphylococcal antibiotics. We are describing the dynamics of resistance over time at two major clinical centers locally, and using genomics, microbiological, and epidemiological tools to test hypotheses to explain the observed patterns.
Title figure by Centers for Disease Control and Prevention (CDC) Report “Antibiotic Resistance Threats in the united States 2013”