Pilot Grants

The Hoffman Program funded eleven Pilot Grants between 2015 and 2019. This modest support gave investigators a chance to carry out preliminary studies with the aim of advancing our understanding of MCS/TILT/DELTA. Most grants explored promising hypotheses on the biological mechanism of chemical sensitization, often by leveraging access to population studies through collaborations with other institutions. Other projects promoted scientific understanding, public awareness, and institutional change to reduce chemical exposures. Find below the summaries of the pilot grants and resulting publications.

Chemical Exposure Studies

Pulmonary Exposure to Aerosolized Cosmetics

Evaluating the effects of inhaled ENPs and nano-enabled products on pulmonary responses to bacterial exposures.

Predicting Chemical Exposures with Silicone Wristbands

Evaluating predictors of chemical exposures in offices world-wide using silicone wristbands.

Maternal Exposures to PFCs and PCBs

Breast milk exosomes and mechanisms of immunotoxicity from perfluorinated compounds (PFCs) and polychlorinated biphenyls (PCBs)

Pulmonary Exposure to Zinc

DELTA: Do Repeated Pulmonary Exposures to Zinc Induce Sensitization or Adaptation?

Epigenetic Research 

Ribosomal DNA as an Epigenetic Modulator

Ribosomal DNA copy number: a novel epigenetic modulator and platform for analyses of adaptation and sensitization to repeated chemical exposures.

Early Life Pollutants Exposure 

Metabolic Diseases Linked to Early Life Pollutant Exposures

Elucidating the role of adipocytokines and insulin-like growth factors in the pathogenesis of metabolic diseases linked to early life environmental pollutant exposures.

Environmental Risk Factors for Autism

The association between maternal air pollution exposure and the risk of autism in Israel.

Environmental Health Initiative

Healthy Green Campus Project: Removing flame retardants from furniture

Raising awareness of the link between health and exposure to everyday toxic chemicals.

Airline-related Studies

Air Crew Uniforms

Relationship between health complaints and the introduction of new uniforms in the Flight Attendant Health Cohort, longitudinal occupational cohort.