Research in my lab is focused on nutritional, genetic and molecular mechanisms of adaptive stress resistance. Our primary interest is in dietary restriction, best known for its ability to extend lifespan in organisms as diverse as roundworms, fruit flies, and yeast, but also with the proven ability to improve metabolic fitness and stress resistance. We are currently exploring how dietary restriction works, and how it may be translated in practical ways to address a wide range of clinical problems. We also study adaptive responses to genotoxic stress, including effects of DNA damage and repair on energy metabolism, in a mouse model of the premature aging disorder Cockayne syndrome. Finally, we are interested in the effects of host nutrition on immunometabolism and infection in a mouse model of malaria.
James R. Mitchell