Select Publications

Selected Publications:

Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, , Treviño-Villarreal JH, Mejia P, Vargas D, Inouye K, Bronson RT, Lee C-H, Neilan E, Kristal BS, Mitchell JR. Increased oxidative phosphorylation in response to acute and chronic DNA damage. npj Aging and Mechanisms of Disease 2016 (in press)


Mejia P, Diez-Silva M, Kamena F, Lu F, Fernandes SM, Seeberger PH, Davis AE III, Mitchell JR. Human C1-Inhibitor suppresses malaria parasite invasion and cytoadhesion via binding to parasite glycosylphosphatidylinositol and host cell receptors. J Infect Dis. 2016 Jan 1;213(1):80-9. doi: 10.1093/infdis/jiv439. Epub 2015 Sep 7. PubMed PMID: 26347576; PubMed Central PMCID: PMC4676549.


Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.  Cell Metab. 2016; 23:1093-112. PMID: 27304509. PMCID: PMC4911707.


Longchamp A, Tao M, Bartelt A, Ding K, Hine C, Mitchell JR, Corpataux M, Kristal BS, Lynch L, Ozaki CK. Surgical Injury Induces Local and Distant Adipose Tissue Browning. Adipocyte 2015 Nov 20;5(2):163-74. Pubmed PMID: 27386152; Pubmed PMCID: PMC4916868


Robertson LT, Treviño-Villarreal JH, Mejia P, Grondin Y, Harputlugil E, Hine C, Vargas D, Zheng H, Ozaki CK, Kristal BS, Simpson SJ, Mitchell JR. Protein and calorie restriction contribute additively to protection from renal ischemia reperfusion injury partly via leptin reduction in male mice. J Nutr. 2015 Aug;145(8):1717-27. doi: 10.3945/jn.114.199380. Epub 2015 Jun 3. PubMed PMID: 26041674; PubMed PMCID:PMC4516761.


Pedro Mejia, J. Humberto Treviño -Villarreal, Christopher Hine, Eylul Harputlugil, Samantha Lang, Ediz Calay, Rick Rogers, Dyann Wirth, Manoj Duraisingh, and James R. MitchellNature Communications, online January 30, 2015, 6:6050 doi: 10.1038/ncomms7050 (2014).PMCID:PMC 4313624


Hine C, Mitchell JR. Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway. Exp Ger 2014 PMID: 25523462


Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell 2014 PMID:25542313


Harputlugil E, Hine C, Vargas D, Robertson L, Peng W, Manning BD, Mitchell JR. Tsc1 required for benefits of dietary protein restriction on hepatic insulin sensitivity and stress resistance. Cell Reports 2014 Aug 21;8(4):1160-70. PMID: 25131199


Mauro CR, Tao M, Peng Y, Treviño-Villerreal JH, Longchamp A, Kristal BS, Ozaki CK, Mitchell JR. Pre-operative dietary restriction reduces intimal hyperplasia and protects from ischemia reperfusion injury. J Vasc Surg 2014 Aug 8. pii: S0741-5214(14)01295-6. PMID: 25124359


Hine C, Mitchell JR. Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging. Cell Stem Cell 2014 Jun 5;14(6): 704-5. PMID: 24905161


Fang EF, Scheibye-Knudsen M, Brace L, Mitchell JR, Nilsen H, Croteau DL, Bohr VA. Defective mitophagy in xeroderma pigmentosum group A via attenuation of the NAD+/SIRT1 pathway. Cell 2014 May 8;157(4):882-96. PMID: 24813611.


Varendi K, Airavaara M, Anttila J, Vose S, Saarma M, Mitchell JR, Andressoo JO. Preoperative fasting and short-term dietary protein restriction are neuroprotective in a rat focal stroke model. PLoS One 2014 Apr 4;9(4): e93911. PMID: 24705386


Robertson LT, Mitchell JR. Benefits of fasting and short-term dietary restriction in mammals. Exp. Gerontol. 2013 Feb 1. pii: S0531-5565(13)00024-7. PMID: 23376627


Gallinetti J, Harputlugil E, Mitchell JR. Amino acid sensing and translational control in dietary restriction-mediated longevity and stress resistance: contrasting roles of signal transducing kinases Gcn2 and mTOR. Biochem. J 2013 449:1-10. PMID: 23216249


Nguyen B, Tao M, Yu P, Mauro C, Seidman MA, Wang YE, Mitchell JR, Ozaki CK. Pre-operative diet impacts the adipose tissue response to surgical trauma. Surgery 2013 Apr:153(4). PMID: 23274098


Brace L, Vose SC, Vargas DF, Zhao S, Wang X-P, Mitchell JR. Lifespan extension by dietary intervention in a mouse model of Cockayne Syndrome uncouples early postnatal development from segmental progeria. Aging Cell 2013 Dec;12(6):1144-7. PMID: 23895664


Mitchell JR, Beckman JA, Nguyen LL, Ozaki CK. Reducing elective vascular surgery perioperative risk with brief preoperative dietary restriction. Surgery 2013 Apr:153(4):594-598. PMID: 23218877


van de Ven M, Andressoo JO, van der Horst GTJ, Hoeijmakers JHJ, Mitchell JR. Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models. DNA Repair 2012 Nov 1:11(11):874-83. PMID: 23046824


Hine C, Mitchell JR. NRF2 and the phase II response in acute stress resistance induced by dietary restriction. J Clin. Exp. Path. 2012. PMID: 23505614


Peng W, Robertson L, Gallinetti J, Mejia P, Vose S, Charlip A, Chu T, Mitchell JR. Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci. Transl. Med. 2012 Jan 25 (4):118ra11. PMID: 22277968


Verweij M, van de Ven M, Mitchell JR, van den Engel S, Hoeijmakers JH, IJzermans JN, de Bruin RW. Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice. Transplantation. 2011 Oct 15;92(7):752-8. PMID: 21926943


Vose S, Mitchell JR. Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes. DNA Repair and Human Health. ed. Vengrova S. Oct 2011. ISBN 978-953-307-612-6


Susa D, Mitchell JR, Verweij M, van de Ven M, Roest H, van den Engel S, Bajema I, Mangundap K, Ijzermans JN, Hoeijmakers JH, de Bruin RW. Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice. Aging Cell, 2009. Volume(2): p. 192-200. PMID: 19338497


Mitchell JR, Verweij M, Brand K, van de Ven M, Goemaere N, van den Engel S, Chu T, Forrer F, Muller C, de Jong M, van IJcken W, IJzermans JN, Hoeijmakers JH, de Bruin RW. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell, 2009. Volume(1): p. 40-53. PMID: 19878145