JBL II: Oct. 1999

2nd Annual John B. Little Symposium

“Radiation and Cancer: Etiology, Treatment and Prevention”

October 3-4, 1999


Sunday, October 3, 1999


Dr. Barry Bloom

Dean, Harvard School of Public Health 

Dr. Joseph D. Brain

Chair, Department of Environmental Health, HSPH

Dr. Karl T. Kelsey

Department of Cancer Cell Biology, HSPH



MODERATOR: Dr. John B. Little

Harvard School of Public Health

Albert J. Fornace, Jr.

National Cancer Institute, National Institutes of Health
“Disruption of the p53-effector gene gadd45 leads to genomic instability, loss of growth control and radiation carcinogenesis”

Masamitsu Honma

National Institute of Health Sciences, Japan
“Requirement of p53 for recombinational DNA repair and genomic integrity”

Zhi-Min Yuan

Harvard School of Public Health

Molecular mechanisms in the regulation of p53 stability”

Andrew J. Grosovsky

University of California, Riverside
“Radiation-induced genomic instability”

Chuan Yuan Li

Duke University Medical Center
“Radiation, genetic instability and cancer gene therapy”

Amy Kronenberg

Lawrence Berkeley National Laboratory
“Programmed cell death and recombination”

Carl Maki

Harvard School of Public Health
“Regulation of p53 ubiquitination and stability”

Yao-Yu Eric Chuang

National Cancer Institute, National Institutes of Health

“Radiation-induced mutagenesis at the autosomal thymidine kinase locus is not elevated in p53-null cells”

Sally A. Amundson

 National Cancer Institute, National Institutes of Health

“cDNA microarrays and the functional genomics of radiation response”

Carol Moore

CUNY Medical School
“Radiation and bleomycin induced DNA repair in a yeast model”

Howard L. Liber

Massachusetts General Hospital

“Mechanisms of radiation-induced mutagenesis”



MODERATOR: Howard L. Liber

 Massachusetts General Hospital

James Ford

Stanford University School of Medicine
“p53 and DNA excision repair”

Malcolm Lippert

Fitchberg State College
“Effect of transcription on mutation in human cells”

F. Andrew Ray

Albany Medical College, Albany, NY
“TNT: T-antigen and telomerase, an explosive combination”

Jeffrey Schwartz

University of Washington Medical Center
“Variations in telomerase metabolism in telomerase-positive human cell lines”

Frederick Wenz

University of Heidelberg, Germany
“Induction of telomerase4 by ionising radiation”

Paul Billings

University of Pennsylvania School of Dentistry
“Expression of potential bifunctional linker portein, Beta ig-3 by human bladder cells”

Yongjia Yu

University of Texas Medical Branch at Galveston

“DNA-PKcs:polymorphism and phenotypic alteration”

Benoit Paquette

Universite de Sherbrooke, Quebec, Canada
“Reactive oxygen species generated by hydrosyestrogens induce DNA strand breaks”

Danièle Brouty-Boyé

INSERM, France
“Understanding the role of microenvironment (fibroblasts) on tumor cells: emanating from studies on the 10T 1/2 model”

Mary Jane Sawey

Temple School of Medicine
“Down-regulation of gap junctional communication: function of malignant progression in mouse skin carcinogenesis”

Monday, October 4, 1999


MODERATOR: S. James Adelstein

Harvard Medical School 

Ralph R. Weichselbaum

University of Chicago
“Activation of cellular genes suppressed by HSV-1”

Patricia Hentosh

Chicago Medical School
“Incorporation of the anti-leukemic drug, 2-chlrorodeoxyadenosine into DNA and its molecular consequences”

Ted Lampidis

University of Miami
“Multidrug resistance and mitochondrial localizing drugs”

James Robertson

East Carolina University, NC
“Protons: still some questions?”

Mark Ritter

University of Wisconsin Hospital and Clinics
“Tumor cell proliferation — clinical implications and therapeutic strategies”

Hans Peter Rutz

Kantonsspital Winterhur, Switzerland
“Coricosteroid induced protection against cytotoxic effects of ionizing radiation and chemotherapeutic agents”

Jerry Williams

Johns Hopkins Oncology Center
“Patterns of radiosensitivity in human tumor cells: a subalpha-alpha-omega analysis”


MODERATOR: Karl T. Kelsey

Harvard School of Public Health

Ann R. Kennedy

University of Pennsylvania School of Medicine
“The beneficial effects of the Bowman-Birk inhibitor in the prevention and treatment of human diseases”

Wu-shou Peter Chang

National Yang Ming University, Taiwan
“Biomedical effects of chronic extremely low dose-rate gamma-irradiation in a human population”

David Yandell

Vermont Cancer Center 

 “Rational approaches to Mutation Screening”

William Toscano

University of Minnesota, School of Public Health
“Sleeping with the ZebraFish–apologies to Luca Brazzi”