JBL III: Oct. 2000

3rd Annual John B. Little Symposium

“Genetic and Cellular Factors in Human Cancer Therapy”

October 20-21, 2000

 

Friday, October 20, 2000

JBL Award Lecture given by Dr. Eric J. Hall

Columbia University

“Radiation, The Double Edged Sword: A Cure and Cause of Cancer”

 

Presentation of John B. Little Award in Radiation Sciences to Dr. Hall

Dr. Warren W. Nichols, Merck Research Laboratories

INTRODUCTION

Dr. Joel S. Bedford

Colorado State University

 

SESSION I: GENETIC DIFFERENCES BETWEEN TUMOR AND NORMAL CELLS:

IMPLICATIONS FOR THERAPY

DISCUSSION LEADER: Simon N. Powell

Massachusetts General Hospital

Wafik El-Deiry

University of Pennsylvania School of Medicine

“Overview of Pathways and Strategies to Selectively Kill Cancer Cells: Targeting p53 and Death Receptor Pathways”

J. Martin Brown

Stanford Medical School

“Apoptosis, p53 and Tumor Response to Therapy”

Stanley Korsmeyer

Dana-Farber Cancer Institute

“Integrating the Cell Death Pathway”

Peter Glazer

Yale School of Medicine

“Radiation Response in Mammalian Cells: DNA Repair Meets Signal Transduction”

David Livingston

 Dana-Farber Cancer Institute

“Functional Analysis of the BRCA1 and 2 Gene Products”

Saturday, October 21, 2000

SESSION II: CELL TO CELL INTERACTIONS

DISCUSSION LEADER: S. J. Adelstein

Harvard Medical School

Rakesh Jain

 Massachusetts General Hospital

“Role of Host-Tumor Interactions in Tumor Angiogenesis and Response to Therapy”

Joseph O’Donoghue

Memorial Sloan Kettering Center

“Targeted Radionuclide Therapy: Where Physics and Biology Meet”

Judah Folkman

Harvard Medical School

“Angiogenesis Research: From Laboratory to Clinic”

John B. Little

Harvard School of Public Health

“Intercellular Transmission of Radiation Damage Signals”

Roger Howell

New Jersey Medical School

“Bystander Effects Caused by Nonuniform Distribution of Radioactivity”

 

 

SESSION III: LONG-TERM CONSEQUENCES OF RADIATION THERAPY: SECONDARY CANCERS

DISCUSSION LEADER: Joseph D. Brain

Harvard School of Public Health

Joseph D. Brain

Harvard School of Public Health

“Introduction: Non-cancer Endpoints”

John D. Boice

International Epidemiologic Institute

“Treatment of Adults with Cancer”

Steven L. Hancock

Stanford Medical School

Factors Affecting Risk of Secondary Cancers and Adverse Cardiac Effects”

Frederick P. Li

Harvard School of Public Health

“Genetic Susceptibility and Secondary Tumors Among Children with Cancer”

Carolyn A. Felix

University of Pennsylvania School of Medicine

“Secondary Leukemias”