JBL IV: Oct. 2001

4th Annual John B. Little Symposium

“Radiation Damage to DNA: Repair and Cellular Response”

October 12-13, 2001

 

Friday, October 12, 2001

JBL Award Lecture given by James L. German

Weill Medical College of Cornell University

“Four Decades of Bloom’s Syndrome”


Presentation of John B. Little Award in Radiation Sciences to Dr. German

Warren W. Nichols, Merck Research Laboratories

SESSION I: CLUSTERED DAMAGE AND COMPLEX INTERACTIONS

DISCUSSION LEADER: S. James Adelstein

Harvard Medical School 

John Ward

University of California, San Diego

“The variety of radiation-induced DNA strand breaks”

Paul W. Doetsch

Emory University School of Medicine

“Transcriptional mutagenesis in prokaryotic and eukaryotic systems”

Sankar Mitra

University of Texas Medical Branch, Galveston

“Effects of oxidative stress on the dynamics of early repair enzymes for oxidative DNA damage in human cells”

Carol Prives

Columbia University

“The expanding roles of p53 and its relatives”

Saturday, October 13, 2001

SESSION II: MECHANISMS OF DOUBLE STRAND BREAK REPAIR

DISCUSSION LEADER: Kathryn D. Held

Massachusetts General Hospital

Maria Jasin

 Memorial Sloan Kettering Cancer Center

“Genomic integrity and double-strand break repair in mammalian cells” 

Alan D. D’Andrea 

Dana-Farber Cancer Institute

“Interactions of the Fanconi anemia proteins and Brca1 in a common pathway”

Fred Alt

Harvard Medical School

“Interplay between non-homologous end joining and cell cycle checkpoint pathways in normal development and tumor suppression”

Tom K. Hei

Columbia University

“Radiation-induced genotoxic damage in mammalian cells: From cytoplasm to nucleus and the bystander phenomenon”

 

SESSION III: CELL RESPONSES TO RADIATION DAMAGE

DISCUSSION LEADER: Bruce Demple

Harvard School of Public Health

James E. Haber

Brandeis University

“Adaptation and recovery following a single chromosome break” 

George Iliakis

Thomas Jefferson University

“Double-strand break repair and cellular responses”

John Petrini

University of Wisconsin

“The Mre11 complex: linking DNA recombination and cell cycle regulation to the suppression of malignancy”

Carrolee Barlow

Salk Institute

Using ATM-deficient mice to study the role of  ATM in damage response pathways”

William F. Morgan

University of Maryland

“Radiation-induced genomic instability and bystander effects: A little goes a long way”