9th Annual JBL Symposium
“The Environment or the Enemy within? Cellular Mechanisms to Offset Genotoxic Threats”
November 3-4, 2006
Friday, November 3, 2006
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WELCOME AND INTRODUCTIONS Drs. John B. Little and Bruce Demple Harvard School of Public Health |
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John B. Little Award Lecture given by Dr. Tomas Lindahl London Research Institute “Human and murine cells deficient in repair of ionizing radiation-induced DNA base damage and anomalous DNA structures” |
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SESSION I: GLOBAL CHANGES AND STRESS RESPONSES |
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DISCUSSION LEADER: Dr. William Toscano University of Minnesota School of Public Health |
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Dr. John Quackenbush Harvard School of Public Health; Dana-Farber Cancer Institute “Extracting biological meaning from high-dimensional datasets” |
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Dr. Mark Boguski Novartis “Systems biology and proteomics in drug and biomarker discovery” |
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Dr. Myriam Gorospe National Institute on Aging “Conveying stress messages: the eventful journey of ribonucleoproteins” |
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Dr. Albert J. Fornace, Jr. Georgetown University “Inhibition of genotoxic and oncogenic stress signaling pathways by Wip1 phosphatase, the product of the Ppm1d oncogene” |
Saturday, November 4, 2006
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SESSION II: GENOME MAINTENANCE AND STABILITY |
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DISCUSSION LEADER: Dr. Karl T. Kelsey Harvard School of Public Health |
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Dr. John B. Little Harvard School of Public Health “Non-targeted effects of radiation: intercellular communication and the bystander effect” |
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Dr. Jac Nickoloff University of New Mexico Health Sciences Center “Roles for metnase, a human histone methylase/nuclease, in double strand break repair, replication stress, and suppression of gene targeting” |
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Dr. Alan D’Andrea Dana-Farber Cancer Institute, Harvard Medical School “The Fanconi Anemia/BRCA pathway and the DNA damage response” |
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Dr. Karlene Cimprich Stanford University Medical School “How do checkpoints get turned on?” |
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SESSION III: SIGNAL RELAYS AND AGING |
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DISCUSSION LEADER: Dr. Zhi-Min Yuan Harvard School of Public Health |
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Dr. Judy Lieberman Harvard Medical School and the CBR Institute for Medical Research “Protein dephosphorylation and DNA damage” |
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Dr. Andre Nussenzweig National Institutes of Health, National Cancer Institute “Early events in the DNA damage response” |
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Dr. Jerry Shay University of Texas Southwestern Medical School “Molecular mechanism initiating senescence” |
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Dr. Michael Karin University of California, School of Medicine “Control of life and death through the IKK-JNK interplay” |