JBL IX: Nov. 2006

9th Annual JBL Symposium

“The Environment or the Enemy within?  Cellular Mechanisms to Offset Genotoxic Threats”

November 3-4, 2006

 

Friday, November 3, 2006

WELCOME AND INTRODUCTIONS

Drs. John B. Little and Bruce Demple

Harvard School of Public Health

John B. Little Award Lecture given by Dr. Tomas Lindahl

London Research Institute 

“Human and murine cells deficient in repair of ionizing radiation-induced DNA base damage and anomalous DNA structures”

SESSION I: GLOBAL CHANGES AND STRESS RESPONSES

DISCUSSION LEADER: Dr. William Toscano

University of Minnesota School of Public Health

Dr. John Quackenbush

Harvard School of Public Health; Dana-Farber Cancer Institute

“Extracting biological meaning from high-dimensional datasets”

Dr. Mark Boguski

Novartis

“Systems biology and proteomics in drug and biomarker discovery”

Dr. Myriam Gorospe

National Institute on Aging

“Conveying stress messages: the eventful journey of ribonucleoproteins”

Dr. Albert J. Fornace, Jr.

Georgetown University

“Inhibition of genotoxic and oncogenic stress signaling pathways by Wip1 phosphatase, the product of the Ppm1d oncogene”

Saturday, November 4, 2006

SESSION II: GENOME MAINTENANCE AND STABILITY

DISCUSSION LEADER: Dr. Karl T. Kelsey

Harvard School of Public Health

Dr. John B. Little

Harvard School of Public Health

“Non-targeted effects of radiation: intercellular communication and the bystander effect”

Dr. Jac Nickoloff

University of New Mexico Health Sciences Center

“Roles for metnase, a human histone methylase/nuclease, in double strand break repair, replication stress, and suppression of gene targeting”

Dr. Alan D’Andrea 

Dana-Farber Cancer Institute, Harvard Medical School

“The Fanconi Anemia/BRCA pathway and the DNA damage response”

Dr. Karlene Cimprich

Stanford University Medical School 

“How do checkpoints get turned on?”

 

SESSION III: SIGNAL RELAYS AND AGING

DISCUSSION LEADER: Dr. Zhi-Min Yuan

Harvard School of Public Health

Dr. Judy Lieberman

Harvard Medical School and the CBR Institute for Medical Research

“Protein dephosphorylation and DNA damage”

Dr. Andre Nussenzweig 

National Institutes of Health, National Cancer Institute

“Early events in the DNA damage response”

Dr. Jerry Shay 

University of Texas Southwestern Medical School

“Molecular mechanism initiating senescence”

Dr. Michael Karin

University of California, School of Medicine

“Control of life and death through the IKK-JNK interplay”