6th Annual JBL Symposium
“Cellular Mechanisms in Genetic Stability and Aging”
October 24-25, 2003
Drs. John B. Little and Gerald T. Chan
Friday, October 24, 2003
WELCOME AND INTRODUCTIONSJohn B. Little, M.D.
Harvard School of Public Health Bruce Demple, Ph.D. Harvard School of Public Health |
John B. Little Award Lecture given by Dr. James E. Cleaver University of California at San Francisco “Xeroderma Pigmentosum – Cancer and Neurodegeneration; Prevention and Therapies” |
SESSION I: STRESS RESPONSES AND CELL SIGNALLING |
DISCUSSION LEADER: Simon N. Powell, Ph.D.Massachusetts General Hospital |
Stephen Elledge, Ph.D.Harvard Medical School
“Sensing and Responding to DNA Damage” |
Sara A. Courtneidge, Ph.D. Van Andel Research Institute
“The Roles of Src and its Substrate Fish in Tumorigenesis“ |
Nikki J. Holbrook, Ph.D.Yale New Haven Hospital
“Factors Contributing to Declines in Stress Tolerance with Aging“ |
Ronald DePinho, M.D.Dana-Farber Cancer Institute, Harvard Medical School
“Modeling Cancer and Cancer Genomes in the Mouse“ |
Saturday, October 25, 2003
SESSION II: MECHANISMS OF AGING |
DISCUSSION LEADER: Andrew Grosovky, Ph.D.University of California, Riverside |
Leonard Guarente, Ph.D.Massachusetts Institute of Technology
“SIR2 Longevity Gene as Mediator of Calorie Restriction in Yeast and Mammals“ |
Tomas A. Prolla, Ph.D.University of Wisconsin
“The Gene Expression Profile Associated with the Aging Process” |
Judith Campisi, Ph.D.Lawrence Berkeley National Laboratory
“Cancer, Aging, and Protecting the Genome” |
Gary Ruvkun, Ph.D.Massachusetts General Hospital
“Mitochondria and Metabolism Involvement in C. elegans Lifespan” |
SESSION III: MECHANISMS OF GENETICS STABILITY |
DISCUSSION LEADER: Amin I. Kassis, Ph.D.Harvard Medical School |
Amato J. Giaccia, Ph.D.Stanford University School of Medicine
“Regulation of Cell Differentiation by Hypoxia“ |
Samuel H. Wilson, M.D.National Institutes of Health, National Institute of Environmental Health Sciences
“Multiple Roles of Base Excision Repair in Mammalian Cells” |
Scott W. Lowe, Ph.D.Cold Spring Harbor Laboratory
“Apoptosis and Senescence in Cancer Development and Therapy” |